Fig. 2

Hierarchy of hematopoietic differentiation stages used as basis for our study. For reasons discussed in the main text, we only considered classical ontological relationships for all analyses (solid lines) and did not include more recent models and their accompanying novel entities. Lymphomyeloid-restricted progenitors (LMPPs, first proposed by [44]) are shown as an example for emerging relationships that are not covered by our data (dotted lines). In this model, MPP, CMP, MEP and GMP are developmental branching points and will be investigated in detail later