Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

Table 2 Objective values for each patient

ID	Parameters	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7
Urinary elimination ratio (%)
1	CPT-11	23.2	25.5	35.5	26.3	17.8	28.1	30.0
2	SN-38	0.4	0.5	0.7	0.5	0.3	0.5	0.6
3	SN-38G	3.1	3.4	4.8	3.6	2.4	3.8	4.0
4	NPC	0.1	0.2	0.2	0.2	0.1	0.2	0.2
5	APC	2.3	2.5	3.5	2.6	1.8	2.8	3.0
Fecal elimination ratio (%)
6	CPT-11	45.3	43.5	35.4	42.7	49.6	41.4	39.9
7	SN-38 + SN-38G	11.9	11.4	9.3	11.2	13.1	10.9	10.5
8	NPC	1.9	1.8	1.5	1.8	2.1	1.7	1.7
9	APC	11.6	11.2	9.1	11.0	12.7	10.6	10.2
Cmax (μg/ml)
10	CPT-11	1.53	1.53	1.53	1.53	1.53	1.53	1.53
11	SN-38	0.04	0.04	0.04	0.04	0.04	0.04	0.04
12	SN-38G	0.09	0.09	0.09	0.09	0.09	0.09	0.09
13	APC	0.19	0.19	0.19	0.19	0.19	0.19	0.19

Cmax, maximum serum concentrations
The total elimination ratio of urine and feces is normalized to the ratio of reported individual information. Ratios of metabolism from CPT-11 to its metabolites and Cmax of all compounds use average values in the report. Cmax of the metabolites are normalized to the amount of CPT-11

ISSN: 1752-0509