BMC Systems Biology

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Systems Biology and Cancer Metabolism Laboratory, Fabian V. Filipp. CC BY-NC-SA

Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Precision targeting offers hope after a life-changing cancer diagnosis. However, some cancers that initially respond to targeted chemotherapy become treatment-resistant — and this may have nothing to do with the drug itself. This blog describes new research helps explain how therapy-resistant cancers arise — findings with important implications for the future of cancer therapy.

Call for papers: Systems Medicine

New Content Item BMC Systems Biology is delighted to announce the launch of a thematic series focused on highlighting original research on the emerging field of 'Systems Medicine', which will review and feature applied translational research on biological mechanisms, including the tailoring of diagnosis, prevention and treatment of disease via a multitude of methods.

Featured article: Image analysis driven single-cell analytics for systems microbiology

Balomenos et al present BaSCA, a novel Bacterial image analysis driven single-cell analytics pipeline, which enables the high throughput analysis, down to the single-cell level, of complex time lapse cell movies with many colonies and potentially thousands of cells in the field of view. The results presented demonstrate its robustness and universality.

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Most accessed

Content type: Research article
| 3 July 2018

Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity

Authors: Bob Strome, Ian Shenyen Hsu, Mitchell Li Cheong Man, Taraneh Zarin, Alex Nguyen Ba and Alan M. Moses
Content type: Research article
| 19 June 2018

How accurate is automated gap filling of metabolic models?

Authors: Peter D. Karp, Daniel Weaver and Mario Latendresse
Content type: Software
| 19 June 2018

RACIPE: a computational tool for modeling gene regulatory circuits using randomization

Authors: Bin Huang, Dongya Jia, Jingchen Feng, Herbert Levine, José N. Onuchic and Mingyang Lu
Content type: Software
| 19 June 2018

DMPy: a Python package for automated mathematical model construction of large-scale metabolic systems

Authors: Robert W. Smith, Rik P. van Rosmalen, Vitor A. P. Martins dos Santos and Christian Fleck
Content type: Methodology article
| 18 June 2018

Dynamic elementary mode modelling of non-steady state flux data

Authors: Abel Folch-Fortuny, Bas Teusink, Huub C.J. Hoefsloot, Age K. Smilde and Alberto Ferrer

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Content type: Research Article
| 3 December 2015

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Authors: Carl D. Christensen, Jan-Hendrik S. Hofmeyr and Johann M. Rohwer
Content type: Research article
| 23 August 2011

Biological interaction networks are conserved at the module level

Authors: Guy E Zinman, Shan Zhong and Ziv Bar-Joseph
Content type: Proceedings
| 12 December 2012

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

Authors: Chuanli Wang, Longyun Guo, Yixue Li and Zhuo Wang
Content type: Database
| 2 October 2013

A comprehensive map of the influenza A virus replication cycle

Authors: Yukiko Matsuoka, Hiromi Matsumae, Manami Katoh, Amie J Eisfeld, Gabriele Neumann, Takeshi Hase, Samik Ghosh, Jason E Shoemaker, Tiago JS Lopes, Tokiko Watanabe, Shinji Watanabe, Satoshi Fukuyama, Hiroaki Kitano and Yoshihiro Kawaoka
Content type: Review
| 13 March 2014

Bioinformatic analysis of proteomics data

Authors: Andreas Schmidt, Ignasi Forne and Axel Imhof

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BMC Series blog

Chronic sleep deprivation could be an important driver of depression in young women

16 July 2018
Brains versus brawn: reduced brain investment in army ant soldiers

13 July 2018
Deep genetic divergence among Bale monkeys in continuous forest and forest fragments

10 July 2018

Aims and scope

BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modelling, quantitative analyses, integration of different levels of information and synthetic biology.

Editor

Alison Cuff, BioMed Central

Section Editors

Nitin Baliga, Institute for Systems Biology
Christina Chan, Michigan State University
Luonan Chen, Chinese Academy of Sciences
Sang Yup Lee, Korea Advanced Institute of Science and Technology
Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
Matteo Pellegrini, University of California, Los Angeles

Nitin Baliga, Section Editor

Nitin Baliga serves as Professor at the Institute for Systems Biology, where he was one of the founding members, and currently serves as the Director and Senior Vice President. He leads a cross-disciplinary team of scientists to address complex problems relevant to global health, personalized medicine, energy, and environment.

Model of the month

From BioModels at EMBL-EBI

May 2018 by Matthew Roberts

New Content Item

Lactococcus lactis has been genetically modified to increase the yield of mannitol and 2,3-butanediol. Costa et al. (2014) presented a mathematical model that provided new targets to further improve metabolite yield.

Read more about the model here

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Get credit for your data

Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Call for papers: Systems Medicine

Featured article: Image analysis driven single-cell analytics for systems microbiology

Articles

Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity

How accurate is automated gap filling of metabolic models?

RACIPE: a computational tool for modeling gene regulatory circuits using randomization

DMPy: a Python package for automated mathematical model construction of large-scale metabolic systems

Dynamic elementary mode modelling of non-steady state flux data

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Biological interaction networks are conserved at the module level

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

A comprehensive map of the influenza A virus replication cycle

Bioinformatic analysis of proteomics data

BMC Series blog

Chronic sleep deprivation could be an important driver of depression in young women

Brains versus brawn: reduced brain investment in army ant soldiers

Deep genetic divergence among Bale monkeys in continuous forest and forest fragments

Aims and scope

Editor

Section Editors

Nitin Baliga, Section Editor

Model of the month

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