BMC Systems Biology

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Systems Biology and Cancer Metabolism Laboratory, Fabian V. Filipp. CC BY-NC-SA

Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Precision targeting offers hope after a life-changing cancer diagnosis. However, some cancers that initially respond to targeted chemotherapy become treatment-resistant — and this may have nothing to do with the drug itself. This blog describes new research helps explain how therapy-resistant cancers arise — findings with important implications for the future of cancer therapy.

Call for papers: Systems Medicine

New Content Item BMC Systems Biology is delighted to announce the launch of a thematic series focused on highlighting original research on the emerging field of 'Systems Medicine', which will review and feature applied translational research on biological mechanisms, including the tailoring of diagnosis, prevention and treatment of disease via a multitude of methods.

Featured article: Image analysis driven single-cell analytics for systems microbiology

Balomenos et al present BaSCA, a novel Bacterial image analysis driven single-cell analytics pipeline, which enables the high throughput analysis, down to the single-cell level, of complex time lapse cell movies with many colonies and potentially thousands of cells in the field of view. The results presented demonstrate its robustness and universality.

Recent
Most accessed

Content type: Methodology article
| 16 May 2018

A powerful nonparametric method for detecting differentially co-expressed genes: distance correlation screening and edge-count test

Authors: Qingyang Zhang
Content type: Review
| 25 April 2018

New perspectives: systems medicine in cardiovascular disease

Authors: Frank Kramer, Steffen Just and Tanja Zeller
Content type: Research
| 24 April 2018

Feedback regulation in a stem cell model with acute myeloid leukaemia

Authors: Jianfeng Jiao, Min Luo and Ruiqi Wang
Content type: Research
| 24 April 2018

Hierarchical combinatorial deep learning architecture for pancreas segmentation of medical computed tomography cancer images

Authors: Min Fu, Wenming Wu, Xiafei Hong, Qiuhua Liu, Jialin Jiang, Yaobin Ou, Yupei Zhao and Xinqi Gong
Content type: Introduction
| 24 April 2018

Integrating data- and model-driven strategies in systems biology

Authors: Yong Wang, Xiang-Sun Zhang and Luonan Chen

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Content type: Research Article
| 3 December 2015

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Authors: Carl D. Christensen, Jan-Hendrik S. Hofmeyr and Johann M. Rohwer
Content type: Research article
| 23 August 2011

Biological interaction networks are conserved at the module level

Authors: Guy E Zinman, Shan Zhong and Ziv Bar-Joseph
Content type: Proceedings
| 12 December 2012

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

Authors: Chuanli Wang, Longyun Guo, Yixue Li and Zhuo Wang
Content type: Database
| 2 October 2013

A comprehensive map of the influenza A virus replication cycle

Authors: Yukiko Matsuoka, Hiromi Matsumae, Manami Katoh, Amie J Eisfeld, Gabriele Neumann, Takeshi Hase, Samik Ghosh, Jason E Shoemaker, Tiago JS Lopes, Tokiko Watanabe, Shinji Watanabe, Satoshi Fukuyama, Hiroaki Kitano and Yoshihiro Kawaoka
Content type: Review
| 13 March 2014

Bioinformatic analysis of proteomics data

Authors: Andreas Schmidt, Ignasi Forne and Axel Imhof

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BMC Series blog

Rehabilitation and economic recovery for torture survivors

18 May 2018
Highlights of the BMC series: April 2018

16 May 2018
The vitamin D paradox in Black Americans

15 May 2018

Aims and scope

BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modelling, quantitative analyses, integration of different levels of information and synthetic biology.

Editor

Alison Cuff, BioMed Central

Section Editors

Nitin Baliga, Institute for Systems Biology
Christina Chan, Michigan State University
Luonan Chen, Chinese Academy of Sciences
Sang Yup Lee, Korea Advanced Institute of Science and Technology
Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
Matteo Pellegrini, University of California, Los Angeles

Nitin Baliga, Section Editor

Nitin Baliga serves as Professor at the Institute for Systems Biology, where he was one of the founding members, and currently serves as the Director and Senior Vice President. He leads a cross-disciplinary team of scientists to address complex problems relevant to global health, personalized medicine, energy, and environment.

Model of the month

From BioModels at EMBL-EBI

April 2018 by Rahuman Sheriff

New Content Item

Cell cycle arrest in G2 phase by DNA damage is released before the complete repair of all lesions. Jaiswal et al. (2017) mathematically modelled the ATM,ATR, Wip1 and Plk1 pathways to explore why

Read more about the model here

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Get credit for your data

Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Call for papers: Systems Medicine

Featured article: Image analysis driven single-cell analytics for systems microbiology

Articles

A powerful nonparametric method for detecting differentially co-expressed genes: distance correlation screening and edge-count test

New perspectives: systems medicine in cardiovascular disease

Feedback regulation in a stem cell model with acute myeloid leukaemia

Hierarchical combinatorial deep learning architecture for pancreas segmentation of medical computed tomography cancer images

Integrating data- and model-driven strategies in systems biology

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Biological interaction networks are conserved at the module level

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

A comprehensive map of the influenza A virus replication cycle

Bioinformatic analysis of proteomics data

BMC Series blog

Rehabilitation and economic recovery for torture survivors

Highlights of the BMC series: April 2018

The vitamin D paradox in Black Americans

Aims and scope

Editor

Section Editors

Nitin Baliga, Section Editor

Model of the month

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BMC Systems Biology

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