BMC Systems Biology

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Systems Biology and Cancer Metabolism Laboratory, Fabian V. Filipp. CC BY-NC-SA

Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Precision targeting offers hope after a life-changing cancer diagnosis. However, some cancers that initially respond to targeted chemotherapy become treatment-resistant — and this may have nothing to do with the drug itself. This blog describes new research helps explain how therapy-resistant cancers arise — findings with important implications for the future of cancer therapy.

Call for papers: Systems Medicine

New Content Item BMC Systems Biology is delighted to announce the launch of a thematic series focused on highlighting original research on the emerging field of 'Systems Medicine', which will review and feature applied translational research on biological mechanisms, including the tailoring of diagnosis, prevention and treatment of disease via a multitude of methods.

Featured article: Image analysis driven single-cell analytics for systems microbiology

Balomenos et al present BaSCA, a novel Bacterial image analysis driven single-cell analytics pipeline, which enables the high throughput analysis, down to the single-cell level, of complex time lapse cell movies with many colonies and potentially thousands of cells in the field of view. The results presented demonstrate its robustness and universality.

Recent
Most accessed

Content type: Methodology article
| 12 October 2018

Dynamic Optimization with Particle Swarms (DOPS): a meta-heuristic for parameter estimation in biochemical models

Authors: Adithya Sagar, Rachel LeCover, Christine Shoemaker and Jeffrey Varner
Content type: Research article
| 3 October 2018

Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics

Authors: Daniel Cook, Sirisha Achanta, Jan B. Hoek, Babatunde A. Ogunnaike and Rajanikanth Vadigepalli
Content type: Research article
| 26 September 2018

Multi-component gene network design as a survival strategy in diverse environments

Authors: Xinyue Luo, Ruijie Song and Murat Acar
Content type: Software
| 26 September 2018

Escher-FBA: a web application for interactive flux balance analysis

Authors: Elliot Rowe, Bernhard O. Palsson and Zachary A. King
Content type: Research article
| 25 September 2018

The synthetic histone-binding regulator protein PcTF activates interferon genes in breast cancer cells

Authors: Kimberly C. Olney, David B. Nyer, Daniel A. Vargas, Melissa A. Wilson Sayres and Karmella A. Haynes

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Content type: Research Article
| 3 December 2015

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Authors: Carl D. Christensen, Jan-Hendrik S. Hofmeyr and Johann M. Rohwer
Content type: Research article
| 23 August 2011

Biological interaction networks are conserved at the module level

Authors: Guy E Zinman, Shan Zhong and Ziv Bar-Joseph
Content type: Proceedings
| 12 December 2012

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

Authors: Chuanli Wang, Longyun Guo, Yixue Li and Zhuo Wang
Content type: Database
| 2 October 2013

A comprehensive map of the influenza A virus replication cycle

Authors: Yukiko Matsuoka, Hiromi Matsumae, Manami Katoh, Amie J Eisfeld, Gabriele Neumann, Takeshi Hase, Samik Ghosh, Jason E Shoemaker, Tiago JS Lopes, Tokiko Watanabe, Shinji Watanabe, Satoshi Fukuyama, Hiroaki Kitano and Yoshihiro Kawaoka
Content type: Review
| 13 March 2014

Bioinformatic analysis of proteomics data

Authors: Andreas Schmidt, Ignasi Forne and Axel Imhof

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BMC Series blog

Improving the conversation between doctors and patients about antibiotic benefits and harms for coughs and colds

17 October 2018
Relationships between neurological and psychiatric disorders: Could migraine and ADHD be correlated?

16 October 2018
Media multitasking may be linked to altered perception of other people

11 October 2018

Aims and scope

BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modelling, quantitative analyses, integration of different levels of information and synthetic biology.

Editor

Alison Cuff, BioMed Central

Section Editors

Nitin Baliga, Institute for Systems Biology
Christina Chan, Michigan State University
Luonan Chen, Chinese Academy of Sciences
Sang Yup Lee, Korea Advanced Institute of Science and Technology
Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
Matteo Pellegrini, University of California, Los Angeles

Nitin Baliga, Section Editor

Nitin Baliga serves as Professor at the Institute for Systems Biology, where he was one of the founding members, and currently serves as the Director and Senior Vice President. He leads a cross-disciplinary team of scientists to address complex problems relevant to global health, personalized medicine, energy, and environment.

Model of the month

From BioModels at EMBL-EBI

May 2018 by Matthew Roberts

New Content Item

Lactococcus lactis has been genetically modified to increase the yield of mannitol and 2,3-butanediol. Costa et al. (2014) presented a mathematical model that provided new targets to further improve metabolite yield.

Read more about the model here

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BMC Systems Biology

Get credit for your data

Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Call for papers: Systems Medicine

Featured article: Image analysis driven single-cell analytics for systems microbiology

Articles

Dynamic Optimization with Particle Swarms (DOPS): a meta-heuristic for parameter estimation in biochemical models

Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics

Multi-component gene network design as a survival strategy in diverse environments

Escher-FBA: a web application for interactive flux balance analysis

The synthetic histone-binding regulator protein PcTF activates interferon genes in breast cancer cells

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Biological interaction networks are conserved at the module level

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

A comprehensive map of the influenza A virus replication cycle

Bioinformatic analysis of proteomics data

BMC Series blog

Improving the conversation between doctors and patients about antibiotic benefits and harms for coughs and colds

Relationships between neurological and psychiatric disorders: Could migraine and ADHD be correlated?

Media multitasking may be linked to altered perception of other people

Aims and scope

Editor

Section Editors

Nitin Baliga, Section Editor

Model of the month

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BMC Systems Biology

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