BMC Systems Biology

Get credit for your data

Are you holding on to data that you've not yet published? You can get recognition for it by publishing a data note in BMC Research Notes.

Systems Biology and Cancer Metabolism Laboratory, Fabian V. Filipp. CC BY-NC-SA

Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Precision targeting offers hope after a life-changing cancer diagnosis. However, some cancers that initially respond to targeted chemotherapy become treatment-resistant — and this may have nothing to do with the drug itself. This blog describes new research helps explain how therapy-resistant cancers arise — findings with important implications for the future of cancer therapy.

Call for papers: Systems Medicine

New Content Item BMC Systems Biology is delighted to announce the launch of a thematic series focused on highlighting original research on the emerging field of 'Systems Medicine', which will review and feature applied translational research on biological mechanisms, including the tailoring of diagnosis, prevention and treatment of disease via a multitude of methods.

Featured article: Image analysis driven single-cell analytics for systems microbiology

Balomenos et al present BaSCA, a novel Bacterial image analysis driven single-cell analytics pipeline, which enables the high throughput analysis, down to the single-cell level, of complex time lapse cell movies with many colonies and potentially thousands of cells in the field of view. The results presented demonstrate its robustness and universality.

Recent
Most accessed

Content type: Research article
| 17 December 2018

Reframing gene essentiality in terms of adaptive flexibility

Authors: Gabriela I. Guzmán, Connor A. Olson, Ying Hefner, Patrick V. Phaneuf, Edward Catoiu, Lais B. Crepaldi, Lucas Goldschmidt Micas, Bernhard O. Palsson and Adam M. Feist
Content type: Research article
| 17 December 2018

Qualitative modelling of the interplay of inflammatory status and butyrate in the human gut: a hypotheses about robust bi-stability

Authors: Gunter Neumann, Rebecca Wall, Ignacio Rangel, Tatiana M. Marques and Dirk Repsilber
Content type: Research
| 14 December 2018

MICRAT: a novel algorithm for inferring gene regulatory networks using time series gene expression data

Authors: Bei Yang, Yaohui Xu, Andrew Maxwell, Wonryull Koh, Ping Gong and Chaoyang Zhang
Content type: Research
| 14 December 2018

Systems biology analysis reveals new insights into invasive lung cancer

Authors: Dan Li, William Yang, Carolyn Arthur, Jun S. Liu, Carolina Cruz-Niera and Mary Qu Yang
Content type: Research
| 14 December 2018

Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer

Authors: Mengjie Guo, Sicheng Lu, Hongming Huang, Yaohui Wang, Mary Q. Yang, Ye Yang, Zhimin Fan, Bin Jiang and Youping Deng

Most recent articles RSS

View all articles

Content type: Research Article
| 3 December 2015

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Authors: Carl D. Christensen, Jan-Hendrik S. Hofmeyr and Johann M. Rohwer
Content type: Research article
| 23 August 2011

Biological interaction networks are conserved at the module level

Authors: Guy E Zinman, Shan Zhong and Ziv Bar-Joseph
Content type: Proceedings
| 12 December 2012

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

Authors: Chuanli Wang, Longyun Guo, Yixue Li and Zhuo Wang
Content type: Database
| 2 October 2013

A comprehensive map of the influenza A virus replication cycle

Authors: Yukiko Matsuoka, Hiromi Matsumae, Manami Katoh, Amie J Eisfeld, Gabriele Neumann, Takeshi Hase, Samik Ghosh, Jason E Shoemaker, Tiago JS Lopes, Tokiko Watanabe, Shinji Watanabe, Satoshi Fukuyama, Hiroaki Kitano and Yoshihiro Kawaoka
Content type: Review
| 13 March 2014

Bioinformatic analysis of proteomics data

Authors: Andreas Schmidt, Ignasi Forne and Axel Imhof

Most accessed articles RSS

View all articles

BMC Series blog

Lessons learned and best practices from the Polio Eradication Programme in Nigeria

13 December 2018
Highlights of the BMC series: November 2018

11 December 2018
Human Rights Day: What roles do physicians play in human rights issues?

10 December 2018

Aims and scope

BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modelling, quantitative analyses, integration of different levels of information and synthetic biology.

Editor

Alison Cuff, BioMed Central

Section Editors

Nitin Baliga, Institute for Systems Biology
Christina Chan, Michigan State University
Luonan Chen, Chinese Academy of Sciences
Sang Yup Lee, Korea Advanced Institute of Science and Technology
Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
Matteo Pellegrini, University of California, Los Angeles

Nitin Baliga, Section Editor

Nitin Baliga serves as Professor at the Institute for Systems Biology, where he was one of the founding members, and currently serves as the Director and Senior Vice President. He leads a cross-disciplinary team of scientists to address complex problems relevant to global health, personalized medicine, energy, and environment.

Model of the month

From BioModels at EMBL-EBI

November 2018

New Content Item

Proctor (2016) created a model to see the effect ageing and PTH hormone has on the signalling pathways that maintain the bone remodelling process. The authors ran simulations to identify possible treatments to prevent bone loss.

Read more about the model here

Latest Tweets

BMC Systems Biology

Get credit for your data

Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Call for papers: Systems Medicine

Featured article: Image analysis driven single-cell analytics for systems microbiology

Articles

Reframing gene essentiality in terms of adaptive flexibility

Qualitative modelling of the interplay of inflammatory status and butyrate in the human gut: a hypotheses about robust bi-stability

MICRAT: a novel algorithm for inferring gene regulatory networks using time series gene expression data

Systems biology analysis reveals new insights into invasive lung cancer

Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Biological interaction networks are conserved at the module level

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

A comprehensive map of the influenza A virus replication cycle

Bioinformatic analysis of proteomics data

BMC Series blog

Lessons learned and best practices from the Polio Eradication Programme in Nigeria

Highlights of the BMC series: November 2018

Human Rights Day: What roles do physicians play in human rights issues?

Aims and scope

Editor

Section Editors

Nitin Baliga, Section Editor

Model of the month

Latest Tweets

Follow

2017 Journal Metrics

BMC Systems Biology

Contact us