BMC Systems Biology

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Systems Biology and Cancer Metabolism Laboratory, Fabian V. Filipp. CC BY-NC-SA

Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Precision targeting offers hope after a life-changing cancer diagnosis. However, some cancers that initially respond to targeted chemotherapy become treatment-resistant — and this may have nothing to do with the drug itself. This blog describes new research helps explain how therapy-resistant cancers arise — findings with important implications for the future of cancer therapy.

Call for papers: Systems Medicine

New Content Item BMC Systems Biology is delighted to announce the launch of a thematic series focused on highlighting original research on the emerging field of 'Systems Medicine', which will review and feature applied translational research on biological mechanisms, including the tailoring of diagnosis, prevention and treatment of disease via a multitude of methods.

Featured article: Image analysis driven single-cell analytics for systems microbiology

Balomenos et al present BaSCA, a novel Bacterial image analysis driven single-cell analytics pipeline, which enables the high throughput analysis, down to the single-cell level, of complex time lapse cell movies with many colonies and potentially thousands of cells in the field of view. The results presented demonstrate its robustness and universality.

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Content type: Research Article
| 12 April 2018

Evolution of computational models in BioModels Database and the Physiome Model Repository

Authors: Martin Scharm, Tom Gebhardt, Vasundra Touré, Andrea Bagnacani, Ali Salehzadeh-Yazdi, Olaf Wolkenhauer and Dagmar Waltemath
Content type: Research
| 11 April 2018

Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis

Authors: Petronela Buiga, Ari Elson, Lydia Tabernero and Jean-Marc Schwartz
Content type: Research
| 11 April 2018

ncRNA-disease association prediction based on sequence information and tripartite network

Authors: Takuya Mori, Hayliang Ngouv, Morihiro Hayashida, Tatsuya Akutsu and Jose C. Nacher
Content type: Research
| 11 April 2018

KDiamend: a package for detecting key drivers in a molecular ecological network of disease

Authors: Mengxuan Lyu, Jiaxing Chen, Yiqi Jiang, Wei Dong, Zhou Fang and Shuaicheng Li
Content type: Methodology
| 11 April 2018

Discovery of Boolean metabolic networks: integer linear programming based approach

Authors: Yushan Qiu, Hao Jiang, Wai-Ki Ching and Xiaoqing Cheng

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Content type: Research Article
| 3 December 2015

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Authors: Carl D. Christensen, Jan-Hendrik S. Hofmeyr and Johann M. Rohwer
Content type: Research article
| 23 August 2011

Biological interaction networks are conserved at the module level

Authors: Guy E Zinman, Shan Zhong and Ziv Bar-Joseph
Content type: Proceedings
| 12 December 2012

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

Authors: Chuanli Wang, Longyun Guo, Yixue Li and Zhuo Wang
Content type: Database
| 2 October 2013

A comprehensive map of the influenza A virus replication cycle

Authors: Yukiko Matsuoka, Hiromi Matsumae, Manami Katoh, Amie J Eisfeld, Gabriele Neumann, Takeshi Hase, Samik Ghosh, Jason E Shoemaker, Tiago JS Lopes, Tokiko Watanabe, Shinji Watanabe, Satoshi Fukuyama, Hiroaki Kitano and Yoshihiro Kawaoka
Content type: Review
| 13 March 2014

Bioinformatic analysis of proteomics data

Authors: Andreas Schmidt, Ignasi Forne and Axel Imhof

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BMC Series blog

Attention to metabolic energy disturbance is needed to treat relapse of heroin

20 April 2018
New thematic series: Veterinary antimicrobial resistance and antimicrobial use

19 April 2018
Speedy species divergence and the curious case of the blind cavefish

18 April 2018

Aims and scope

BMC Systems Biology is an open access journal publishing original peer-reviewed research articles in experimental and theoretical aspects of the function of biological systems at the molecular, cellular or organismal level, in particular those addressing the engineering of biological systems, network modelling, quantitative analyses, integration of different levels of information and synthetic biology.

Editor

Alison Cuff, BioMed Central

Section Editors

Nitin Baliga, Institute for Systems Biology
Christina Chan, Michigan State University
Luonan Chen, Chinese Academy of Sciences
Sang Yup Lee, Korea Advanced Institute of Science and Technology
Pedro Mendes, Univ. of Manchester/Univ. Connecticut Health Center
Matteo Pellegrini, University of California, Los Angeles

Nitin Baliga, Section Editor

Nitin Baliga serves as Professor at the Institute for Systems Biology, where he was one of the founding members, and currently serves as the Director and Senior Vice President. He leads a cross-disciplinary team of scientists to address complex problems relevant to global health, personalized medicine, energy, and environment.

Model of the month

From BioModels at EMBL-EBI

April 2018 by Rahuman Sheriff

New Content Item

Cell cycle arrest in G2 phase by DNA damage is released before the complete repair of all lesions. Jaiswal et al. (2017) mathematically modelled the ATM,ATR, Wip1 and Plk1 pathways to explore why

Read more about the model here

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Featured blog: Systems biology study identifies acquired cancer resistance beyond mutations

Call for papers: Systems Medicine

Featured article: Image analysis driven single-cell analytics for systems microbiology

Articles

Evolution of computational models in BioModels Database and the Physiome Model Repository

Regulation of dual specificity phosphatases in breast cancer during initial treatment with Herceptin: a Boolean model analysis

ncRNA-disease association prediction based on sequence information and tripartite network

KDiamend: a package for detecting key drivers in a molecular ecological network of disease

Discovery of Boolean metabolic networks: integer linear programming based approach

Tracing regulatory routes in metabolism using generalised supply-demand analysis

Biological interaction networks are conserved at the module level

Systematic Comparison of C3 and C4 Plants Based on Metabolic Network Analysis

A comprehensive map of the influenza A virus replication cycle

Bioinformatic analysis of proteomics data

BMC Series blog

Attention to metabolic energy disturbance is needed to treat relapse of heroin

New thematic series: Veterinary antimicrobial resistance and antimicrobial use

Speedy species divergence and the curious case of the blind cavefish

Aims and scope

Editor

Section Editors

Nitin Baliga, Section Editor

Model of the month

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