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  1. Research Article

    Cooperative binding mitigates the high-dose hook effect

    The high-dose hook effect (also called prozone effect) refers to the observation that if a multivalent protein acts as a linker between two parts of a protein complex, then increasing the amount of linker prot...

    Ranjita Dutta Roy, Christian Rosenmund and Melanie I. Stefan

    BMC Systems Biology 2017 11:74

    Published on: 14 August 2017

  2. Methodology Article

    Manatee invariants reveal functional pathways in signaling networks

    Signal transduction pathways are important cellular processes to maintain the cell’s integrity. Their imbalance can cause severe pathologies. As signal transduction pathways feature complex regulations, they f...

    Leonie Amstein, Jörg Ackermann, Jennifer Scheidel, Simone Fulda, Ivan Dikic and Ina Koch

    BMC Systems Biology 2017 11:72

    Published on: 28 July 2017

  3. Research Article

    Modeling de novo granulation of anaerobic sludge

    A unique combination of mechanical, physiochemical and biological forces influences granulation during processes of anaerobic digestion. Understanding this process requires a systems biology approach due to th...

    Anna Doloman, Honey Varghese, Charles D. Miller and Nicholas S. Flann

    BMC Systems Biology 2017 11:69

    Published on: 17 July 2017

  4. Research Article

    Development of an in silico method for the identification of subcomplexes involved in the biogenesis of multiprotein complexes in Saccharomyces cerevisiae

    Large sets of protein-protein interaction data coming either from biological experiments or predictive methods are available and can be combined to construct networks from which information about various cell ...

    Annie Glatigny, Philippe Gambette, Alexa Bourand-Plantefol, Geneviève Dujardin and Marie-Hélène Mucchielli-Giorgi

    BMC Systems Biology 2017 11:67

    Published on: 11 July 2017

  5. Research Article

    An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia

    Triple-negative breast cancer lacks estrogen, progesterone, and HER2 receptors and is thus not possible to treat with targeted therapies for these receptors. Therefore, a greater understanding of triple-negati...

    Kerri-Ann Norton, Travis Wallace, Niranjan B. Pandey and Aleksander S. Popel

    BMC Systems Biology 2017 11:68

    Published on: 11 July 2017

  6. Research Article

    Reconstruction of the microalga Nannochloropsis salina genome-scale metabolic model with applications to lipid production

    Nannochloropsis salina (= Eustigmatophyceae) is a marine microalga which has become a biotechnological target because of its high capacity to produce polyunsaturated fatty acids and tr...

    Nicolás Loira, Sebastian Mendoza, María Paz Cortés, Natalia Rojas, Dante Travisany, Alex Di Genova, Natalia Gajardo, Nicole Ehrenfeld and Alejandro Maass

    BMC Systems Biology 2017 11:66

    Published on: 4 July 2017

  7. Research Article

    Gene expression profiles and signaling mechanisms in α2B-adrenoceptor-evoked proliferation of vascular smooth muscle cells

    α2-adrenoceptors are important regulators of vascular tone and blood pressure. Regulation of cell proliferation is a less well investigated consequence of α2-adrenoceptor activation. We have previously shown that...

    Anna Huhtinen, Vesa Hongisto, Asta Laiho, Eliisa Löyttyniemi, Dirk Pijnenburg and Mika Scheinin

    BMC Systems Biology 2017 11:65

    Published on: 28 June 2017

  8. Research Article

    Comprehensive benchmarking of Markov chain Monte Carlo methods for dynamical systems

    In quantitative biology, mathematical models are used to describe and analyze biological processes. The parameters of these models are usually unknown and need to be estimated from experimental data using stat...

    Benjamin Ballnus, Sabine Hug, Kathrin Hatz, Linus Görlitz, Jan Hasenauer and Fabian J. Theis

    BMC Systems Biology 2017 11:63

    Published on: 24 June 2017

  9. Methodology Article

    Evaluation and improvement of the regulatory inference for large co-expression networks with limited sample size

    Co-expression has been widely used to identify novel regulatory relationships using high throughput measurements, such as microarray and RNA-seq data. Evaluation studies on co-expression network analysis metho...

    Wenbin Guo, Cristiane P. G. Calixto, Nikoleta Tzioutziou, Ping Lin, Robbie Waugh, John W. S. Brown and Runxuan Zhang

    BMC Systems Biology 2017 11:62

    Published on: 19 June 2017

  10. Research article

    Remodeling adipose tissue through in silico modulation of fat storage for the prevention of type 2 diabetes

    Type 2 diabetes is one of the leading non-infectious diseases worldwide and closely relates to excess adipose tissue accumulation as seen in obesity. Specifically, hypertrophic expansion of adipose tissues is ...

    Thierry Chénard, Frédéric Guénard, Marie-Claude Vohl, André Carpentier, André Tchernof and Rafael J. Najmanovich

    BMC Systems Biology 2017 11:60

    Published on: 12 June 2017

  11. Research article

    Single-cell study links metabolism with nutrient signaling and reveals sources of variability

    The yeast AMPK/SNF1 pathway is best known for its role in glucose de/repression. When glucose becomes limited, the Snf1 kinase is activated and phosphorylates the transcriptional repressor Mig1, which is then ...

    Niek Welkenhuysen, Johannes Borgqvist, Mattias Backman, Loubna Bendrioua, Mattias Goksör, Caroline B Adiels, Marija Cvijovic and Stefan Hohmann

    BMC Systems Biology 2017 11:59

    Published on: 5 June 2017

  12. Research Article

    Clostridium butyricum maximizes growth while minimizing enzyme usage and ATP production: metabolic flux distribution of a strain cultured in glycerol

    The increase in glycerol obtained as a byproduct of biodiesel has encouraged the production of new industrial products, such as 1,3-propanediol (PDO), using biotechnological transformation via bacteria like Clost...

    Luis Miguel Serrano-Bermúdez, Andrés Fernando González Barrios, Costas D. Maranas and Dolly Montoya

    BMC Systems Biology 2017 11:58

    Published on: 1 June 2017

  13. Methodology Article

    Parameter inference for stochastic single-cell dynamics from lineage tree data

    With the advance of experimental techniques such as time-lapse fluorescence microscopy, the availability of single-cell trajectory data has vastly increased, and so has the demand for computational methods sui...

    Irena Kuzmanovska, Andreas Milias-Argeitis, Jan Mikelson, Christoph Zechner and Mustafa Khammash

    BMC Systems Biology 2017 11:52

    Published on: 26 April 2017

  14. Research Article

    A scalable metabolite supplementation strategy against antibiotic resistant pathogen Chromobacterium violaceum induced by NAD+/NADH+ imbalance

    The leading edge of the global problem of antibiotic resistance necessitates novel therapeutic strategies. This study develops a novel systems biology driven approach for killing antibiotic resistant pathogens...

    Deepanwita Banerjee, Dharmeshkumar Parmar, Nivedita Bhattacharya, Avinash D. Ghanate, Venkateswarlu Panchagnula and Anu Raghunathan

    BMC Systems Biology 2017 11:51

    Published on: 26 April 2017

  15. Database

    SSER: Species specific essential reactions database

    Essential reactions are vital components of cellular networks. They are the foundations of synthetic biology and are potential candidate targets for antimetabolic drug design. Especially if a single reaction i...

    Abraham A. Labena, Yuan-Nong Ye, Chuan Dong, Fa-Z Zhang and Feng-Biao Guo

    BMC Systems Biology 2017 11:50

    Published on: 19 April 2017

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