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  1. Content type: Research article

    Clinical integration of systems biology approaches is gaining in importance in the course of digital revolution in modern medicine. We present our results of the analysis of an extended mathematical model desc...

    Authors: Jan Christoph Banck and Dennis Görlich

    Citation: BMC Systems Biology 2019 13:18

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  2. Content type: Research article

    Understanding what determines the between-host variability in infection dynamics is a key issue to better control the infection spread. In particular, pathogen clearance is desirable over rebounds for the heal...

    Authors: Natacha Go, Suzanne Touzeau, Zeenath Islam, Catherine Belloc and Andrea Doeschl-Wilson

    Citation: BMC Systems Biology 2019 13:15

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  3. Content type: Correction

    It was highlighted that the original article [1] contained a mistake in the grant number in the Funding section of the Declarations, and in the legend of Fig. 6. This Correction article shows the incorrect and...

    Authors: Qichang Yang, Jing Wu, Jian Zhao, Tianyi Xu, Zhongming Zhao, Xiaofeng Song and Ping Han

    Citation: BMC Systems Biology 2019 13:14

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    The original article was published in BMC Systems Biology 2018 12:128

  4. Content type: Research article

    Cholesterylester transfer protein (CETP) modulates the composition of various lipoproteins associated with cardiovascular disease. Despite its central role in lipoprotein metabolism, its mode of action is stil...

    Authors: Martin Jansen, Gerhard Puetz, Michael M. Hoffmann and Karl Winkler

    Citation: BMC Systems Biology 2019 13:12

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  5. Content type: Correction

    It was highlighted that the original article [1] contained a typesetting error in the last name of Allon Canaan. This was incorrectly captured as Allon Canaann in the original article which has since been upda...

    Authors: Mary Qu Yang, Sherman M. Weissman, William Yang, Jialing Zhang, Allon Canaan and Renchu Guan

    Citation: BMC Systems Biology 2019 13:13

    Published on:

    The original article was published in BMC Systems Biology 2018 12:114

  6. Content type: Research article

    There is little published regarding metabolism of Salinispora species. In continuation with efforts performed towards this goal, this study is focused on new insights into the metabolism of the three-identified s...

    Authors: Carolina A. Contador, Vida Rodríguez, Barbara A. Andrews and Juan A. Asenjo

    Citation: BMC Systems Biology 2019 13:11

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  7. Content type: Research article

    Parkinson’s disease (PD) is the second most common neurodegenerative disease, and it is a multifactorial disease with no definite diagnostic index. The aim of this study is to construct a molecular network to ...

    Authors: Xiaoting Liu, Jinhu Chen, Tianyuan Guan, Hui Yao, Wenpei Zhang, Zhenlong Guan and Yanqin Wang

    Citation: BMC Systems Biology 2019 13:10

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    The Correction to this article has been published in BMC Systems Biology 2019 13:20

  8. Content type: Research article

    Liver has the unique ability to regenerate following injury, with a wide range of variability of the regenerative response across individuals. Existing computational models of the liver regeneration are largel...

    Authors: Babita K. Verma, Pushpavanam Subramaniam and Rajanikanth Vadigepalli

    Citation: BMC Systems Biology 2019 13:9

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  9. Content type: Research article

    Psoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have bee...

    Authors: Yuqi Zhao, Deepali Jhamb, Le Shu, Douglas Arneson, Deepak K. Rajpal and Xia Yang

    Citation: BMC Systems Biology 2019 13:8

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  10. Content type: Research article

    The Notch signaling pathway is involved in cell fate decision and developmental patterning in diverse organisms. A receptor molecule, Notch (N), and a ligand molecule (in this case Delta or Dl) are the central...

    Authors: Elaine R. Reynolds, Ryan Himmelwright, Christopher Sanginiti and Jeffrey O. Pfaffmann

    Citation: BMC Systems Biology 2019 13:7

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  11. Content type: Research article

    The lack of a continuous long-term in vitro culture system for Plasmodium vivax severely limits our knowledge of pathophysiology of the most widespread malaria parasite. To gain direct understanding of P. vivax h...

    Authors: Swamy Rakesh Adapa, Rachel A. Taylor, Chengqi Wang, Richard Thomson-Luque, Leah R. Johnson and Rays H. Y. Jiang

    Citation: BMC Systems Biology 2019 13:5

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  12. Content type: Methodology article

    A recurrent problem in genome-scale metabolic models (GEMs) is to correctly represent lipids as biomass requirements, due to the numerous of possible combinations of individual lipid species and the correspond...

    Authors: Benjamín J. Sánchez, Feiran Li, Eduard J. Kerkhoven and Jens Nielsen

    Citation: BMC Systems Biology 2019 13:4

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  13. Content type: Research article

    The formation of acetate by fast-growing Escherichia coli (E. coli) is a commonly observed phenomenon, often referred to as overflow metabolism. Among various studies that have been carried over decades, a recent...

    Authors: Hong Zeng and Aidong Yang

    Citation: BMC Systems Biology 2019 13:3

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  14. Content type: Methodology article

    Aggregation of high-throughput biological data using pathway-based approaches is useful to associate molecular results to functional features related to the studied phenomenon. Biological pathways communicate ...

    Authors: Guillermo de Anda-Jáuregui, Kai Guo, Brett A. McGregor, Eva L. Feldman and Junguk Hur

    Citation: BMC Systems Biology 2019 13:1

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  15. Content type: Research

    Many mathematical and statistical models and algorithms have been proposed to do biomarker identification in recent years. However, the biomarkers inferred from different datasets suffer a lack of reproducibil...

    Authors: Ke Zhang, Wei Geng and Shuqin Zhang

    Citation: BMC Systems Biology 2018 12(Suppl 9):135

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    This article is part of a Supplement: Volume 12 Supplement 9

  16. Content type: Research

    With the rapid accumulation of genomic data, it has become a challenge issue to annotate and interpret these data. As a representative, Gene set enrichment analysis has been widely used to interpret large mole...

    Authors: Dong Wang, Jie Li, Rui Liu and Yadong Wang

    Citation: BMC Systems Biology 2018 12(Suppl 9):133

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  17. Content type: Research

    Predicting disease causative genes (or simply, disease genes) has played critical roles in understanding the genetic basis of human diseases and further providing disease treatment guidelines. While various co...

    Authors: Sezin Kircali Ata, Le Ou-Yang, Yuan Fang, Chee-Keong Kwoh, Min Wu and Xiao-Li Li

    Citation: BMC Systems Biology 2018 12(Suppl 9):138

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  18. Content type: Research

    Signaling pathways are the key biological mechanisms that transduce extracellular signals to affect transcription factor mediated gene regulation within cells. A number of computational methods have been devel...

    Authors: Md Humayun Kabir, Ralph Patrick, Joshua W. K. Ho and Michael D. O’Connor

    Citation: BMC Systems Biology 2018 12(Suppl 9):120

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  19. Content type: Research

    Discovering reliable protein biomarkers is one of the most important issues in biomedical research. The ELISA is a traditional technique for accurate quantitation of well-known proteins. Recently, the multiple...

    Authors: Jongsu Jun, Jungsoo Gim, Yongkang Kim, Hyunsoo Kim, Su Jong Yu, Injun Yeo, Jiyoung Park, Jeong-Ju Yoo, Young Youn Cho, Dong Hyeon Lee, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Seungyeoun Lee, Jung-Hwan Yoon, Youngsoo Kim…

    Citation: BMC Systems Biology 2018 12(Suppl 9):123

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  20. Content type: Research

    Hot spot residues are functional sites in protein interaction interfaces. The identification of hot spot residues is time-consuming and laborious using experimental methods. In order to address the issue, many...

    Authors: Quanya Liu, Peng Chen, Bing Wang, Jun Zhang and Jinyan Li

    Citation: BMC Systems Biology 2018 12(Suppl 9):132

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  21. Content type: Research

    Drug repositioning is a promising and efficient way to discover new indications for existing drugs, which holds the great potential for precision medicine in the post-genomic era. Many network-based approaches...

    Authors: Zhen Tian, Zhixia Teng, Shuang Cheng and Maozu Guo

    Citation: BMC Systems Biology 2018 12(Suppl 9):134

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  22. Content type: Research

    Evaluating the significance for a group of genes or proteins in a pathway or biological process for a disease could help researchers understand the mechanism of the disease. For example, identifying related pa...

    Authors: Menglan Cai and Limin Li

    Citation: BMC Systems Biology 2018 12(Suppl 9):141

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  23. Content type: Research

    During the identification of potential candidates, computational prediction of drug-target interactions (DTIs) is important to subsequent expensive validation in wet-lab. DTI screening considers four scenarios...

    Authors: Jian-Yu Shi, An-Qi Zhang, Shao-Wu Zhang, Kui-Tao Mao and Siu-Ming Yiu

    Citation: BMC Systems Biology 2018 12(Suppl 9):136

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  24. Content type: Research

    MicroRNA (miRNA) plays a key role in regulation mechanism of human biological processes, including the development of disease and disorder. It is necessary to identify potential miRNA biomarkers for various hu...

    Authors: Yiwen Sun, Zexuan Zhu, Zhu-Hong You, Zijie Zeng, Zhi-An Huang and Yu-An Huang

    Citation: BMC Systems Biology 2018 12(Suppl 9):121

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  25. Content type: Research

    Evidences have increasingly indicated that lncRNAs (long non-coding RNAs) are deeply involved in important biological regulation processes leading to various human complex diseases. Experimental investigations...

    Authors: Yaping Wen, Guosheng Han and Vo V. Anh

    Citation: BMC Systems Biology 2018 12(Suppl 9):122

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  26. Content type: Research

    One of the important steps in the process of assembling a genome sequence from short reads is scaffolding, in which the contigs in a draft genome are ordered and oriented into scaffolds. Currently, several sca...

    Authors: Kun-Tze Chen, Hsin-Ting Shen and Chin Lung Lu

    Citation: BMC Systems Biology 2018 12(Suppl 9):139

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 9

  27. Content type: Software

    Biological Regulatory Networks (BRNs) are responsible for developmental and maintenance related functions in organisms. These functions are implemented by the dynamics of BRNs and are sensitive to regulations ...

    Authors: Muhammad Tariq Saeed, Jamil Ahmad, Jan Baumbach, Josch Pauling, Aamir Shafi, Rehan Zafar Paracha, Asad Hayat and Amjad Ali

    Citation: BMC Systems Biology 2018 12:146

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  28. Content type: Research

    Circular RNAs (circRNAs) have recently been found to be expressed in human brain tissue, and many lines ofevidence indicate that circRNAs play regulatory roles in neurodevelopment. Proliferation and differenti...

    Authors: Qichang Yang, Jing Wu, Jian Zhao, Tianyi Xu, Zhongming Zhao, Xiaofeng Song and Ping Han

    Citation: BMC Systems Biology 2018 12(Suppl 8):128

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

    The Correction to this article has been published in BMC Systems Biology 2019 13:14

  29. Content type: Research

    The mammalian brain is organized into regions with specific biological functions and properties. These regions have distinct transcriptomes, but little is known whether they may also differ in their metabolome...

    Authors: William T. Choi, Mehmet Tosun, Hyun-Hwan Jeong, Cemal Karakas, Fatih Semerci, Zhandong Liu and Mirjana Maletić-Savatić

    Citation: BMC Systems Biology 2018 12(Suppl 8):127

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  30. Content type: Research

    A fundamental problem for translational genomics is to find optimal therapies based on gene regulatory intervention. Dynamic intervention involves a control policy that optimally reduces a cost function based ...

    Authors: Roozbeh Dehghannasiri, Mohammad Shahrokh Esfahani and Edward R. Dougherty

    Citation: BMC Systems Biology 2018 12(Suppl 8):137

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  31. Content type: Research

    Chromatin interactions medicated by genomic elements located throughout the genome play important roles in gene regulation and can be identified with the technologies such as high-throughput chromosome conform...

    Authors: Yulin Dai, Chao Li, Guangsheng Pei, Xiao Dong, Guohui Ding, Zhongming Zhao, Yixue Li and Peilin Jia

    Citation: BMC Systems Biology 2018 12(Suppl 8):140

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  32. Content type: Research

    Self-interacting Proteins (SIPs) plays a critical role in a series of life function in most living cells. Researches on SIPs are important part of molecular biology. Although numerous SIPs data be provided, tr...

    Authors: Yan-Bin Wang, Zhu-Hong You, Xiao Li, Tong-Hai Jiang, Li Cheng and Zhan-Heng Chen

    Citation: BMC Systems Biology 2018 12(Suppl 8):129

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  33. Content type: Research

    Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set based analyses improve the biologists’ capability to discover functional relevance of their ...

    Authors: Hung-I Harry Chen, Yu-Chiao Chiu, Tinghe Zhang, Songyao Zhang, Yufei Huang and Yidong Chen

    Citation: BMC Systems Biology 2018 12(Suppl 8):142

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  34. Content type: Research

    As protein is the basic unit of cell function and biological pathway, shotgun proteomics, the large-scale analysis of proteins, is contributing greatly to our understanding of disease mechanisms. Proteomics st...

    Authors: Jie Ren, Bo Wang and Jing Li

    Citation: BMC Systems Biology 2018 12(Suppl 8):130

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  35. Content type: Research

    Gene signatures are important to represent the molecular changes in the disease genomes or the cells in specific conditions, and have been often used to separate samples into different groups for better resear...

    Authors: Saurav Mallik and Zhongming Zhao

    Citation: BMC Systems Biology 2018 12(Suppl 8):126

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  36. Content type: Research

    Traumatic brain injury (TBI) represents a critical health problem of which timely diagnosis and treatment remain challenging. TBI is a result of an external force damaging brain tissue, accompanied by delayed ...

    Authors: F. Anthony San Lucas, John Redell, Dash Pramod and Yin Liu

    Citation: BMC Systems Biology 2018 12(Suppl 8):131

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  37. Content type: Research

    Single-cell RNA sequencing (scRNA-Seq) is an emerging technology that has revolutionized the research of the tumor heterogeneity. However, the highly sparse data matrices generated by the technology have posed...

    Authors: Yu-Chiao Chiu, Tzu-Hung Hsiao, Li-Ju Wang, Yidong Chen and Yu-Hsuan Joni Shao

    Citation: BMC Systems Biology 2018 12(Suppl 8):124

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  38. Content type: Introduction

    Between June 10–12, 2018, the International Conference on Intelligent Biology and Medicine (ICIBM 2018) was held in Los Angeles, California, USA. The conference included 11 scientific sessions, four tutorials,...

    Authors: Kai Wang, Xiaoming Liu, Yan Guo, Zhijin Wu, Degui Zhi, Jianhua Ruan and Zhongming Zhao

    Citation: BMC Systems Biology 2018 12(Suppl 8):125

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 8

  39. Content type: Research article

    Essentiality assays are important tools commonly utilized for the discovery of gene functions. Growth/no growth screens of single gene knockout strain collections are also often utilized to test the predictive...

    Authors: Gabriela I. Guzmán, Connor A. Olson, Ying Hefner, Patrick V. Phaneuf, Edward Catoiu, Lais B. Crepaldi, Lucas Goldschmidt Micas, Bernhard O. Palsson and Adam M. Feist

    Citation: BMC Systems Biology 2018 12:143

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  40. Content type: Research article

    Gut microbiota interacts with the human gut in multiple ways. Microbiota composition is altered in inflamed gut conditions. Likewise, certain microbial fermentation products as well as the lipopolysaccharides ...

    Authors: Gunter Neumann, Rebecca Wall, Ignacio Rangel, Tatiana M. Marques and Dirk Repsilber

    Citation: BMC Systems Biology 2018 12:144

    Published on:

  41. Content type: Research

    Nowadays, because of the huge economic burden on society causing by obesity and diabetes, they turn into the most serious public health challenges in the world. To reveal the close and complex relationships be...

    Authors: Guannan He, Yanchun Liang, Yan Chen, William Yang, Jun S. Liu, Mary Qu Yang and Renchu Guan

    Citation: BMC Systems Biology 2018 12(Suppl 7):116

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 7

  42. Content type: Research

    Single-cell RNA sequencing (scRNA-seq) technology provides an effective way to study cell heterogeneity. However, due to the low capture efficiency and stochastic gene expression, scRNA-seq data often contains...

    Authors: Mary Qu Yang, Sherman M. Weissman, William Yang, Jialing Zhang, Allon Canaann and Renchu Guan

    Citation: BMC Systems Biology 2018 12(Suppl 7):114

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 7

    The Correction to this article has been published in BMC Systems Biology 2019 13:13

  43. Content type: Research

    Accumulation of amyloid β-peptide (Aβ) is implicated in the pathogenesis and development of Alzheimer’s disease (AD). Neuron-enriched miRNA was aberrantly regulated and may be associated with the pathogenesis ...

    Authors: Ling Hu, Rong Zhang, Qiong Yuan, Yinping Gao, Mary Q. Yang, Chunxiang Zhang, Jiankun Huang, Yufei Sun, William Yang, Jack Y. Yang, Zhen-li Min, Jing Cheng, Youping Deng and Xiamin Hu

    Citation: BMC Systems Biology 2018 12(Suppl 7):119

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 7

  44. Content type: Research

    Reconstruction of gene regulatory networks (GRNs), also known as reverse engineering of GRNs, aims to infer the potential regulation relationships between genes. With the development of biotechnology, such as ...

    Authors: Bei Yang, Yaohui Xu, Andrew Maxwell, Wonryull Koh, Ping Gong and Chaoyang Zhang

    Citation: BMC Systems Biology 2018 12(Suppl 7):115

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 7

  45. Content type: Research

    Adenocarcinoma in situ (AIS) is a pre-invasive lesion in the lung and a subtype of lung adenocarcinoma. The patients with AIS can be cured by resecting the lesion completely. In contrast, the patients with inv...

    Authors: Dan Li, William Yang, Carolyn Arthur, Jun S. Liu, Carolina Cruz-Niera and Mary Qu Yang

    Citation: BMC Systems Biology 2018 12(Suppl 7):117

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 7

  46. Content type: Research

    Bladder cancer (BC) is the most common cancer of the urinary bladder and upper tract, in which the clinical management is limited. AURKA (aurora kinase A) has been identified as an oncogene in cancer developme...

    Authors: Mengjie Guo, Sicheng Lu, Hongming Huang, Yaohui Wang, Mary Q. Yang, Ye Yang, Zhimin Fan, Bin Jiang and Youping Deng

    Citation: BMC Systems Biology 2018 12(Suppl 7):118

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 7

2017 Journal Metrics

  • Citation Impact
    2.05 - 2-year Impact Factor
    2.505 - 5-year Impact Factor
    0.689 - Source Normalized Impact per Paper (SNIP)
    1.109 - SCImago Journal Rank (SJR)

    Usage 
    852,052 downloads


    Social Media Impact
    523 mentions

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