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  1. Content type: Review

    Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance...

    Authors: Frank Kramer, Steffen Just and Tanja Zeller

    Citation: BMC Systems Biology 2018 12:57

    Published on:

  2. Content type: Research

    Differential gene expression analysis using RNA-seq data is a popular approach for discovering specific regulation mechanisms under certain environmental settings. Both gene ontology (GO) and KEGG pathway enri...

    Authors: Kuo-Sheng Hung, Chung-Chi Hsiao, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou, Wen-Der Wang and Yet-Ran Chen

    Citation: BMC Systems Biology 2018 12(Suppl 4):45

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  3. Content type: Research

    Essential proteins are necessary for the survival and development of cells. The identification of essential proteins can help to understand the minimal requirements for cellular life and it also plays an impor...

    Authors: Xiujuan Lei, Ming Fang, Fang-Xiang Wu and Luonan Chen

    Citation: BMC Systems Biology 2018 12(Suppl 4):46

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  4. Content type: Research

    WD40 repeat proteins constitute one of the largest families in eukaryotes, and widely participate in various fundamental cellular processes by interacting with other molecules. Based on individual WD40 protein...

    Authors: Xu-Dong Zou, Ke An, Yun-Dong Wu and Zhi-Qiang Ye

    Citation: BMC Systems Biology 2018 12(Suppl 4):41

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  5. Content type: Research

    Promoter is an important sequence regulation element, which is in charge of gene transcription initiation. In prokaryotes, σ70 promoters regulate the transcription of most genes. The promoter recognition has been...

    Authors: Wenying He, Cangzhi Jia, Yucong Duan and Quan Zou

    Citation: BMC Systems Biology 2018 12(Suppl 4):44

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  6. Content type: Research

    Finding potential drug targets is a crucial step in drug discovery and development. Recently, resources such as the Library of Integrated Network-Based Cellular Signatures (LINCS) L1000 database provide gene e...

    Authors: Limin Li, Xiao He and Karsten Borgwardt

    Citation: BMC Systems Biology 2018 12(Suppl 4):55

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  7. Content type: Research

    Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia that usually presents in infancy. In order to explore the molecular mechanisms of wild and mutated samples from DBA patients were exposed to bioi...

    Authors: Abbas Khan, Arif Ali, Muhammad Junaid, Chang Liu, Aman Chandra Kaushik, William C. S. Cho and Dong-Qing Wei

    Citation: BMC Systems Biology 2018 12(Suppl 4):39

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  8. Content type: Research

    Identifying complexes from PPI networks has become a key problem to elucidate protein functions and identify signal and biological processes in a cell. Proteins binding as complexes are important roles of life...

    Authors: Zehua Zhang, Jian Song, Jijun Tang, Xinying Xu and Fei Guo

    Citation: BMC Systems Biology 2018 12(Suppl 4):40

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  9. Content type: Research

    Rice (Oryza sativa) is one of the most important grain crops, which serves as food source for nearly half of the world population. The study of rice development process as well as related strategies for productio...

    Authors: Fangzhou Shen, Xueting Wu, Luoxi Shi, Hang Zhang, Yangmin Chen, Xiaoquan Qi, Zhuo Wang and Xuan Li

    Citation: BMC Systems Biology 2018 12(Suppl 4):47

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  10. Content type: Research

    One central building block of population genetics is the fixation probability. It is a probabilistic understanding of the eventual fate of new mutations. Moreover, the fixation probability of new beneficial mu...

    Authors: Fangshu Cui and Bo Yuan

    Citation: BMC Systems Biology 2018 12(Suppl 4):48

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  11. Content type: Research

    Uncertainties exist in many biological systems, which can be classified as random uncertainties and fuzzy uncertainties. The former can usually be dealt with using stochastic methods, while the latter have to ...

    Authors: Fei Liu, Siyuan Chen, Monika Heiner and Hengjie Song

    Citation: BMC Systems Biology 2018 12(Suppl 4):42

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  12. Content type: Research

    Gastric Carcinoma is one of the most lethal cancer around the world, and is also the most common cancers in Eastern Asia. A lot of differentially expressed genes have been detected as being associated with Gas...

    Authors: Wentao Dai, Quanxue Li, Bing-Ya Liu, Yi-Xue Li and Yuan-Yuan Li

    Citation: BMC Systems Biology 2018 12(Suppl 4):51

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  13. Content type: Research

    The human body is colonized by a vast number of microbes. Microbiota can benefit many normal life processes, but can also cause many diseases by interfering the regular metabolism and immune system. Recent stu...

    Authors: Jialu Hu, Yiqun Gao, Yan Zheng and Xuequn Shang

    Citation: BMC Systems Biology 2018 12(Suppl 4):54

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  14. Content type: Research

    The haematopoietic lineages with leukaemia lineages are considered in this paper. In particular, we mainly consider that haematopoietic lineages are tightly controlled by negative feedback inhibition of end-pr...

    Authors: Jianfeng Jiao, Min Luo and Ruiqi Wang

    Citation: BMC Systems Biology 2018 12(Suppl 4):43

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  15. Content type: Research

    Efficient computational recognition and segmentation of target organ from medical images are foundational in diagnosis and treatment, especially about pancreas cancer. In practice, the diversity in appearance ...

    Authors: Min Fu, Wenming Wu, Xiafei Hong, Qiuhua Liu, Jialin Jiang, Yaobin Ou, Yupei Zhao and Xinqi Gong

    Citation: BMC Systems Biology 2018 12(Suppl 4):56

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 4

  16. Content type: Research Article

    A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and refined. Even sm...

    Authors: Martin Scharm, Tom Gebhardt, Vasundra Touré, Andrea Bagnacani, Ali Salehzadeh-Yazdi, Olaf Wolkenhauer and Dagmar Waltemath

    Citation: BMC Systems Biology 2018 12:53

    Published on:

  17. Content type: Research

    Breast cancer and ovarian cancer are hormone driven and are known to have some predisposition genes in common such as the two well known cancer genes BRCA1 and BRCA2. The objective of this study is to compare ...

    Authors: Shuqin Zhang

    Citation: BMC Systems Biology 2018 12(Suppl 1):8

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  18. Content type: Research

    Signaling pathways can be reconstructed by identifying ‘effect types’ (i.e. activation/inhibition) of protein-protein interactions (PPIs). Effect types are composed of ‘directions’ (i.e. upstream/downstream) a...

    Authors: Soorin Yim, Hasun Yu, Dongjin Jang and Doheon Lee

    Citation: BMC Systems Biology 2018 12(Suppl 1):9

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  19. Content type: Research

    Drug-drug interactions (DDIs) always cause unexpected and even adverse drug reactions. It is important to identify DDIs before drugs are used in the market. However, preclinical identification of DDIs requires...

    Authors: Hui Yu, Kui-Tao Mao, Jian-Yu Shi, Hua Huang, Zhi Chen, Kai Dong and Siu-Ming Yiu

    Citation: BMC Systems Biology 2018 12(Suppl 1):14

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  20. Content type: Research article

    For over sixty years, it has been known that mammalian spermatozoa immediately after ejaculation are virtually infertile. They became able to fertilize only after they reside for long time (hours to days) with...

    Authors: Alessandra Ordinelli, Nicola Bernabò, Massimiliano Orsini, Mauro Mattioli and Barbara Barboni

    Citation: BMC Systems Biology 2018 12:52

    Published on:

  21. Content type: Research

    25% of breast cancer patients suffer from aggressive HER2-positive tumours that are characterised by overexpression of the HER2 protein or by its increased tyrosine kinase activity. Herceptin is a major drug u...

    Authors: Petronela Buiga, Ari Elson, Lydia Tabernero and Jean-Marc Schwartz

    Citation: BMC Systems Biology 2018 12(Suppl 1):11

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  22. Content type: Research

    Current technology has demonstrated that mutation and deregulation of non-coding RNAs (ncRNAs) are associated with diverse human diseases and important biological processes. Therefore, developing a novel compu...

    Authors: Takuya Mori, Hayliang Ngouv, Morihiro Hayashida, Tatsuya Akutsu and Jose C. Nacher

    Citation: BMC Systems Biology 2018 12(Suppl 1):37

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  23. Content type: Research

    Microbial abundance profiles are applied widely to understand diseases from the aspect of microbial communities. By investigating the abundance associations of species or genes, we can construct molecular ecol...

    Authors: Mengxuan Lyu, Jiaxing Chen, Yiqi Jiang, Wei Dong, Zhou Fang and Shuaicheng Li

    Citation: BMC Systems Biology 2018 12(Suppl 1):5

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

  24. Content type: Methodology

    Traditional drug discovery methods focused on the efficacy of drugs rather than their toxicity. However, toxicity and/or lack of efficacy are produced when unintended targets are affected in metabolic networks...

    Authors: Yushan Qiu, Hao Jiang, Wai-Ki Ching and Xiaoqing Cheng

    Citation: BMC Systems Biology 2018 12(Suppl 1):7

    Published on:

    This article is part of a Supplement: Volume 12 Supplement 1

Page 1 of 78

2016 Journal Metrics

  • Citation Impact
    2.303 - 2-year Impact Factor
    2.526 - 5-year Impact Factor
    0.735 - Source Normalized Impact per Paper (SNIP)
    1.144 - SCImago Journal Rank (SJR)

    Usage 
    804,289 downloads
    1233 Usage Factor


    Social Media Impact
    134 mentions

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