Skip to main content

Table 1 Top 25 genes returned by the Animal PMT node using the GenMAPP Calcium Channels pathway as a query. The horizontal line indicates the 50% recall point, above which half of the query genes are included.

From: A search engine to identify pathway genes from expression data on multiple organisms

Gene Producta

Symbol

P-valueb

Sc

Nd

Ze

Mf

Bg

Calcium channel, voltage-dependent, beta 2

CACNB2

7.6E-10

yh

y

  

y

Calcium channel, voltage-dependent, L type, alpha 1D

CACNA1D

3.1E-08

y

y

y

y

y

Calcium channel, voltage-dependent, P/Q type, alpha 1A

CACNA1A

1.4E-07

y

y

y

y

 

Regulating synaptic membrane exocytosis 2

RIMS2

1.6E-07

y

y

  

y

MAP-kinase activating death domain

MADD

2.5E-07

y

  

y

 

Contactin 1

CNTN1

6.2E-07

y

y

 

y

 

Glutamate decarboxylase 1

GAD1

7.2E-06

y

y

y

y

 

Ryanodine receptor 2

RYR2

1.2E-05

y

y

y

  

HIVI enhancer binding protein 1

HIVEP1

1.3E-05

y

 

y

y

 

Membrane metallo-endopeptidase

MME

1.8E-05

y

y

y

y

 

Stonin 2

STN2

2.0E-05

y

y

y

 

y

Cholinergic receptor, nicotinic, delta

CHRND

2.0E-05

y

y

y

y

 

Transforming growth factor, beta 1

TGFB1

2.3E-05

y

 

y

y

 

Spectrin, beta, non-erythrocytic 1

SPTBN1

2.4E-05

y

y

y

  

Spectrin, alpha, non-erythrocytic 1

SPTAN1

3.5E-05

y

y

 

y

 

Soc-2 suppressor of clear (C. elegans)

SHOC2

4.0E-05

   

y

 

Protein tyr. Phosph., receptor type, N 2

PTPRN2

4.6E-05

y

  

y

 

Potassium channel, subfamily K, member 3

KCNK3

4.7E-05

y

y

y

y

 

Neurotransmitter transporter, noradrenalin, member 2

SLC6A2

4.9E-05

y

y

y

y

 

Protein tyrosine phosphatase, non-receptor type 4

PTPN4

6.9E-05

y

  

y

 

Ras association (RalGDS/AF-6) domain family 1

RASSF1

7.6E-05

y

 

y

y

 

Troponin T2, cardiac

TNNT2

7.9E-05

 

y

y

 

y

Inositol 1,4,5-trisphosphate 3-kinase B

ITPKB

8.7E-05

y

  

y

 

Ubiquitin specific protease 11

USP11

9.1E-05

y

    

Titin

TTN

1.0E-04

 

y

  

y

  1. aThe HUGO name for the gene. Genes in the original query set are italicized.
  2. bMSGR combined P value. This P value was not adjusted to reflect multiple testing; a Bonferroni correction could be applied by multiplying each by 11 to account for searches at each node in the PMT.
  3. cInvolved in cell – cell or intracellular signaling.
  4. dNeuromuscular function.
  5. ePredicted binding site for the ZIC family of transcription factors.
  6. fPredicted binding site for MAZ or MAZR.
  7. gPredicted binding site for the BRAIN2 transcription factor.
  8. hA "y" indicates that a gene had a positive hit for a particular field.
Back to article page

BMC Systems Biology

ISSN: 1752-0509

Contact us