Velocity and displacement of individual cells and the explant tissue. (A) Velocity (μ m/hr) of single mesendodermal cell (blue) vs. explant average (red). The oscillations in single cell velocity reflect the temporal balance between cadherin and integrin signaling, as well as the Fn gradient under the cell, which is in a gradient across the tissue, but still somewhat random from pixel to pixel. The velocity returns to 0 at the end of the simulation because the leading cell reaches the boundary of the substrate. (B) Displacement (μ m) of single cells over time. Each colored tracing represents the displacement of a single cell in the explant, defined as the distance traveled from the cell's initial position in the simulation space.