|
Metabolite X
|
Metabolite Y
|
r
Met
in WT
|
p
|
r
Met
in mto1
|
p
|
r
Met
in tt4
|
p
|
|---|
|
Fructose
|
Glucose
|
0.94
|
0.0000
|
0.94
|
0.0000
|
0.94
|
0.0000
|
|
Cholesterol
|
Campesterol
|
0.96
|
0.0000
|
0.97
|
0.0000
|
0.96
|
0.0000
|
|
Valine
|
beta-Alanine
|
0.92
|
0.0000
|
0.87
|
0.0001
|
0.96
|
0.0000
|
|
Lysine
|
Tyramine
|
0.91
|
0.0000
|
0.94
|
0.0000
|
0.98
|
0.0000
|
|
Serine
|
Glutamate
|
0.90
|
0.0000
|
0.87
|
0.0001
|
0.93
|
0.0000
|
|
Aspartate
|
Shikimate
|
0.90
|
0.0000
|
0.93
|
0.0000
|
0.97
|
0.0000
|
|
Campesterol
|
beta-Sitosterol
|
0.90
|
0.0000
|
0.98
|
0.0000
|
0.97
|
0.0000
|
|
Succinate
|
Glutamate
|
0.89
|
0.0000
|
0.85
|
0.0002
|
0.92
|
0.0000
|
|
Phenylalanine
|
Tyramine
|
0.88
|
0.0000
|
0.89
|
0.0001
|
0.95
|
0.0000
|
|
Succinate
|
Fumarate
|
0.87
|
0.0000
|
0.86
|
0.0002
|
0.86
|
0.0000
|
|
Glycerol-3-P
|
Inositol-1-P
|
0.85
|
0.0000
|
0.93
|
0.0000
|
0.75
|
0.0001
|
|
Isoleucine
|
Tyramine
|
0.84
|
0.0000
|
0.86
|
0.0002
|
0.90
|
0.0000
|
|
Glutamate
|
Adenosine-5-P
|
0.84
|
0.0000
|
0.86
|
0.0002
|
0.77
|
0.0001
|
|
Valine
|
Threonine
|
0.83
|
0.0000
|
0.88
|
0.0001
|
0.96
|
0.0000
|
|
Cholesterol
|
beta-Sitosterol
|
0.81
|
0.0001
|
0.98
|
0.0000
|
0.97
|
0.0000
|
|
Glutamine
|
Adenosine-5-P
|
0.81
|
0.0001
|
0.92
|
0.0000
|
0.83
|
0.0000
|
- The significant level of the metabolite correlation was set at p < 0.001. Only pairs comprising identified metabolites are listed. The metabolites were defined as those identified on comparison with mass spectra and retention indices (RIs) from the library databases (Golm Metabolome Database [30] and our own library) and with authentic standards. Abbreviations: Glycerol-3-P, glycerol-3-phosphate; Inositol-1-P, myo-inositol-1-phosphate; Adenosine-5-P, adenosine-5-monophosphate.
