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Table 5 Major hubs of the comprehensive lactation network

From: Gene regulatory networks in lactation: identification of global principles using bioinformatics

No. of Links UniProt Accession/HGNC Symbol Protein Name
21 [PIR:P00533]/EGFR Epidermal growth factor receptor precursor
17 [PIR:P04181]/OAT Ornithine aminotransferase, mitochondrial
14 [PIR:P35520]/CBS Cystathionine beta-synthase
13 [PIR:O60674]/JAK2 Tyrosine-protein kinase JAK2
12 [PIR:P04626]/ERBB2 Receptor tyrosine-protein kinase erbB-2 precursor
12 [PIR:P40763]/STAT3 Signal transducer and activator of transcription 3
12 [PIR:P36543]/ATP6V1E1 Vacuolar ATP synthase subunit E
11 [PIR:P38398]/BRCA1 Breast cancer type 1 susceptibility protein
11 [PIR:P42229]/STAT5A Signal transducer and activator of transcription 5A
11 [PIR:P52209]/PGD 6-phosphogluconate dehydrogenase, decarboxylating
11 [PIR:Q00341]/HDLBP Vigilin
11 [PIR:P35606]/COPB2 Coatomer subunit beta
10 [PIR:P10912]/GHR Growth hormone receptor precursor
10 [PIR:P29350]/PTPN6 Tyrosine-protein phosphatase non-receptor type 6
10 [PIR:P06730]/EIF4E Eukaryotic translation initiation factor 4E
10 [PIR:P49591]/SARS Seryl-tRNA synthetase, cytoplasmic
10 [PIR:Q15437]/SEC23B Protein transport protein Sec23B
10 [PIR:O14929]/HAT1 Histone acetyltransferase type B catalytic subunit
9 [PIR:O14543]/SOCS3 Suppressor of cytokine signaling 3
9 [PIR:P35568]/IRS1 Insulin receptor substrate 1
9 [PIR:O15524]/SOCS1 Suppressor of cytokine signaling 1
9 [PIR:Q15796]/SMAD2 Mothers against decapentaplegic homolog 2
9 [PIR:P61960]/UFM1 Ubiquitin-fold modifier 1 precursor
8 [PIR:P06213]/INSR Insulin receptor precursor
8 [PIR:O75821]/EIF3S4 Eukaryotic translation initiation factor 3 subunit 4
8 [PIR:P17676]/CEBPB CCAAT/enhancer-binding protein beta
8 [PIR:P04150]/NR3C1 Glucocorticoid receptor