(A) Generalized view of the utilization of glucose by yeast growing in a glucose medium. Only reactions with relative flux-rates greater than 1 relative to a glucose uptake of 100 (arbitrary flux units) are shown (blue numbers). The protein names represent enzymes responsible for the respective reaction. Three notable interaction clusters of enzymes can be found indicated by orange, cyan, and red color. (B) Interaction cluster of enzymes involved in fermentative glycolysis. The enzymes are ordered in clockwise direction according to the catabolic step during the process. Black edges indicate interaction in the protein-protein interaction network. (C) Interaction clusters of enzymes of the TCA-cycle as well as the prior reactions of the pyruvate kinase (PYK1) and pyruvate dehydrogenase (PDH).