
rPIN

fPIN

ePIN


Correlation between

r

pValue

r

pValue

r

pValue


Connectivity~Flux rate of nodes

0.15

4.76E06

0.23

1.08E04

0.25

8.99E05

Centrality~Flux rate of nodes

0.14

2.16E05

0.11

1.24E02

0.32

9.34E13

Flux Rate~Flux rate of neighbors

0.24*

5.25E25

0.52

1.20E41

0.52

1.45E40

 Pearson correlation coefficient, r, and associated pvalues between connectivity (degree), centrality as judged by betweenness of enzymes (nodes in PINs) and the respective relative flux rates, as well as the correlation coefficient of the relative flux rates between neighboring (physically interacting) enzymes in the three PINs examined in this study.
 *Correlation coefficient, r, differs in rPIN from values obtained in fPIN and ePIN, because enzyme pairs are included in the rPIN that were filtered out in the other two PINs because of inconsistent subcellular localization annotation. They are identical for the fPIN and ePIN as the two networks contain the same set of enzymes.