Illustration of how Arena3D can show connections between different data types and cluster data. The layer in the top centre position shows the 9 proteins associated with Huntingtin. We selected rasa1 protein and highlighted its connections to GO terms using our novel hierarchical layout (left image). In addition, we show connections from the nine Huntingtin-related proteins to a group of associated chemicals (bottom, center). These chemicals are shown clustered by affinity propagation, and by tree clustering (right image). In both cases the clustering is based on Tanimoto scores. The figure also illustrates how layers can be moved and rotated to allow better views on the data.