Figure 2

A simplified lipid network interconnecting several species that affect actin nucleation on purified phagosomes. The qualitative effect on actin nucleation is shown in brackets (+, activation; -, inhibition; 0, no effect). B. Branch of the network shown in A that was found to be active in purified phagosomal fractions. The numbers refer to the reactions in sub-model II. In red are the radioactive species detected in the experimental assays (see Fig. 1 and 3).