Figure 5

Topological properties and level of co-regulation interaction. Plots of the (a) clustering coefficient (C), (b) efficiency (E) and (c) cost (σ) against the minimum number of common regulated genes (g _S ) required to draw a link between to nodes in the TF-projected network. We observe that for g _S equal to one and for the two species, a higher value is assigned to C, E and σ of randomized networks in comparison with the original TF's networks. However, while for E. coli network C, E and σ show a decreasing behavior as g _S increases, these quantities in the randomized version show a faster decay, such that for g _S > 2, they become smaller than the corresponding values of the original networks. For random projected networks, we show mean values ± standard error from 10² independent realizations.