Calculation of the digital control type confidence (CTC). (a) The effective TRNs (red) within the entire RegulonDB TRN (gray), mapped on the circular genome of E. coli. Only the three intra-strain experiments are shown. (b) The effective TRNs (orange) within the entire RegulonDB TRN (gray) for a single null model realisation. The effective TRNs of the null models are less densely connected. (c) The frequency distribution of R for 10,000 null models together with the actual values of R from the graphs shown in (a) and (b).