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Table 3 Top ten functions/diseases and their respective top ten signaling pathways in low fertility group spermatozoa.

From: Comprehensive proteomic analysis of bovine spermatozoa of varying fertility rates and identification of biomarkers associated with fertility

  Signaling Pathways
Functions & Diseases Cell cycle:G2/M DN Adamage check point regulation Integrin signaling Apoptosis signaling MAPK signaling Amyloid Processing VEGF signaling G-protein coupled receptor signaling PTEN signaling Actin Cyto-skeleton signaling Axonal guidance signaling
1.Cell cycle 10 11 11 10 5 8 8 10 10 7
2.Cell morphology 3 26 13 18 7 11 18 14 31 26
3.Post translational modification 9 12 9 11 9 5 11 9 14 11
4.Cellular assembly and Organization 3 18 4 10 5 5 7 4 23 20
5.Lipid metabolism 0 2 3 5 5 3 5 2 2 4
6.Small molecule biochemistry 5 9 10 11 8 4 13 7 11 11
7.Connective tissue disorder 1 12 1 11 2 4 10 6 11 1
8.Gene Expression 8 6 8 16 6 5 16 11 6 8
9.Cell death 7 17 14 17 8 8 14 13 15 18
10.Reproductive system disease 9 5 6 9 2 7 4 8 14 12
  1. MAPK: Mitogen Activated Protein Kinase; VEGF: Vascular Endothelial Growth Factor; PTEN: Phosphatase and tensin homolog deleted on chromosome ten.