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Table 3 Top ten functions/diseases and their respective top ten signaling pathways in low fertility group spermatozoa.
| Signaling Pathways | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Functions & Diseases | Cell cycle:G2/M DN Adamage check point regulation | Integrin signaling | Apoptosis signaling | MAPK signaling | Amyloid Processing | VEGF signaling | G-protein coupled receptor signaling | PTEN signaling | Actin Cyto-skeleton signaling | Axonal guidance signaling |
| 1.Cell cycle | 10 | 11 | 11 | 10 | 5 | 8 | 8 | 10 | 10 | 7 |
| 2.Cell morphology | 3 | 26 | 13 | 18 | 7 | 11 | 18 | 14 | 31 | 26 |
| 3.Post translational modification | 9 | 12 | 9 | 11 | 9 | 5 | 11 | 9 | 14 | 11 |
| 4.Cellular assembly and Organization | 3 | 18 | 4 | 10 | 5 | 5 | 7 | 4 | 23 | 20 |
| 5.Lipid metabolism | 0 | 2 | 3 | 5 | 5 | 3 | 5 | 2 | 2 | 4 |
| 6.Small molecule biochemistry | 5 | 9 | 10 | 11 | 8 | 4 | 13 | 7 | 11 | 11 |
| 7.Connective tissue disorder | 1 | 12 | 1 | 11 | 2 | 4 | 10 | 6 | 11 | 1 |
| 8.Gene Expression | 8 | 6 | 8 | 16 | 6 | 5 | 16 | 11 | 6 | 8 |
| 9.Cell death | 7 | 17 | 14 | 17 | 8 | 8 | 14 | 13 | 15 | 18 |
| 10.Reproductive system disease | 9 | 5 | 6 | 9 | 2 | 7 | 4 | 8 | 14 | 12 |
