Table 1 Parameters used in the model with their default value and the studied range. #mol is number of molecules.
From: The dynamics and efficacy of antiviral RNA silencing: A model study
Par. | Meaning | Value units | Studied range | Reference |
|---|---|---|---|---|
r | maximum translation rate * #ribosomes | 15*5000 #mol hr-1 | 30,000 – 750,000 | [38,39] |
o | max rate of complex formation ssRNA | 1 hr-1 | 0.1 – 5 |  |
o d | max rate of complex formation dsRNA | 100 hr-1 | 0 – 1000 |  |
f | ratio of binding plus or minus RNA | 0.9 - | 0 – 1 |  |
h | dsRNA-RDR splitting rate | 10 hr-1 | 1 – 1,000 |  |
v | max virion production rate | 500 #mol hr-1 | 0 – 50,000 |  |
D i | number of Dicer molecules | 500 #mol | 0 – 5,000 |  |
c d | max Dicer cleavage rate for dsRNA | 3 #mol hr-1 | 0 – 20 |  |
c s | max Dicer cleavage rate for ssRNA | 3 #mol hr-1 | 0 – 20 |  |
b 1 | rate of RISC activation | 0.005 #mol -1 hr-1 | 0 – 1 |  |
b 2 | RISC target cleavage rate | 20 #mol -1 hr-1 | 0 – 1,000 | [8] |
i | translation of RISC | 100 #mol hr-1 | 0 – 1,000 |  |
a | amplification (a u , a p and a g ) | 100 #mol hr-1 | 0 – 400 |  |
d r | decay RDR and RISC | 0.1 hr-1 | 0 – 0.5 |  |
d | decay viral ssRNA | 0.5 hr-1 | 0 – 2 |  |
d si | decay siRNA | 2 hr-1 | 0 – 5 | [40] |
k v | saturation of virion production | 10,000 #mol | 1 – 100,000 |  |
k d | saturation of Dicer cleavage | 10,000 #mol | 1 – 100,000 |  |
k t | saturation constant for translation | 1,000 #mol | 1 – 10,000 |  |
k ri | saturation of RISC cleavage | 1,000 #mol | 1 – 10,000 |  |
k r | saturation of complex formation | 1,000 #mol | 1 – 10,000 |  |
k a | saturation amplification | 1000 #mol | 1 – 10,000 |  |