Skip to main content

Advertisement

Table 1 Parameters used in the model with their default value and the studied range. #mol is number of molecules.

From: The dynamics and efficacy of antiviral RNA silencing: A model study

Par. Meaning Value units Studied range Reference
r maximum translation rate * #ribosomes 15*5000 #mol hr-1 30,000 – 750,000 [38,39]
o max rate of complex formation ssRNA 1 hr-1 0.1 – 5  
o d max rate of complex formation dsRNA 100 hr-1 0 – 1000  
f ratio of binding plus or minus RNA 0.9 - 0 – 1  
h dsRNA-RDR splitting rate 10 hr-1 1 – 1,000  
v max virion production rate 500 #mol hr-1 0 – 50,000  
D i number of Dicer molecules 500 #mol 0 – 5,000  
c d max Dicer cleavage rate for dsRNA 3 #mol hr-1 0 – 20  
c s max Dicer cleavage rate for ssRNA 3 #mol hr-1 0 – 20  
b 1 rate of RISC activation 0.005 #mol -1 hr-1 0 – 1  
b 2 RISC target cleavage rate 20 #mol -1 hr-1 0 – 1,000 [8]
i translation of RISC 100 #mol hr-1 0 – 1,000  
a amplification (a u , a p and a g ) 100 #mol hr-1 0 – 400  
d r decay RDR and RISC 0.1 hr-1 0 – 0.5  
d decay viral ssRNA 0.5 hr-1 0 – 2  
d si decay siRNA 2 hr-1 0 – 5 [40]
k v saturation of virion production 10,000 #mol 1 – 100,000  
k d saturation of Dicer cleavage 10,000 #mol 1 – 100,000  
k t saturation constant for translation 1,000 #mol 1 – 10,000  
k ri saturation of RISC cleavage 1,000 #mol 1 – 10,000  
k r saturation of complex formation 1,000 #mol 1 – 10,000  
k a saturation amplification 1000 #mol 1 – 10,000