From: The dynamics and efficacy of antiviral RNA silencing: A model study
Par. | Meaning | Value units | Studied range | Reference |
---|---|---|---|---|
r | maximum translation rate * #ribosomes | 15*5000 #mol hr^{-1} | 30,000 – 750,000 | [38,39] |
o | max rate of complex formation ssRNA | 1 hr^{-1} | 0.1 – 5 | |
o _{ d } | max rate of complex formation dsRNA | 100 hr^{-1} | 0 – 1000 | |
f | ratio of binding plus or minus RNA | 0.9 - | 0 – 1 | |
h | dsRNA-RDR splitting rate | 10 hr^{-1} | 1 – 1,000 | |
v | max virion production rate | 500 #mol hr^{-1} | 0 – 50,000 | |
D _{ i } | number of Dicer molecules | 500 #mol | 0 – 5,000 | |
c _{ d } | max Dicer cleavage rate for dsRNA | 3 #mol hr^{-1} | 0 – 20 | |
c _{ s } | max Dicer cleavage rate for ssRNA | 3 #mol hr^{-1} | 0 – 20 | |
b _{1} | rate of RISC activation | 0.005 #mol ^{-1} hr^{-1} | 0 – 1 | |
b _{2} | RISC target cleavage rate | 20 #mol ^{-1} hr^{-1} | 0 – 1,000 | [8] |
i | translation of RISC | 100 #mol hr^{-1} | 0 – 1,000 | |
a | amplification (a_{ u }, a_{ p }and a_{ g }) | 100 #mol hr^{-1} | 0 – 400 | |
d _{ r } | decay RDR and RISC | 0.1 hr^{-1} | 0 – 0.5 | |
d | decay viral ssRNA | 0.5 hr^{-1} | 0 – 2 | |
d _{ si } | decay siRNA | 2 hr^{-1} | 0 – 5 | [40] |
k _{ v } | saturation of virion production | 10,000 #mol | 1 – 100,000 | |
k _{ d } | saturation of Dicer cleavage | 10,000 #mol | 1 – 100,000 | |
k _{ t } | saturation constant for translation | 1,000 #mol | 1 – 10,000 | |
k _{ ri } | saturation of RISC cleavage | 1,000 #mol | 1 – 10,000 | |
k _{ r } | saturation of complex formation | 1,000 #mol | 1 – 10,000 | |
k _{ a } | saturation amplification | 1000 #mol | 1 – 10,000 |