Figure 2

Temporal Evolution of internalized receptors. Time trajectories of R_{i_cde} (blue) and R_{i_cie} (green) for three different classes of initial conditions. In case A (B) at least one of EGF₀ or R₀ stays below CDE₀ (CDE₀ + CIE₀). In case C, both EGF₀ and R₀ exceed CDE₀ + CIE₀. Initial values were chosen arbitrarily such that these conditions are satisfied. In all three cases CDE₀ = 2.0, CIE₀ = 2.0 and (A) (EGF₀, R₀) = (1.2, 1.5), (1.6, 1.3), (2.3, 1.3), (1.4, 2.5); (B) (2.5, 3.0), (3.1, 2.4), (3.1, 4.5), (5.0, 2.8); (C) (4.3, 4.7), (5.0, 5.2), (5.5, 5.0), (5.3, 6.0).