Figure 3

Integrated pathway map of signalling in the macrophage. The diagram includes the interferon signalling, NF-κB, apoptosis and toll-like receptor pathways, all represented as one integrated pathway due to their overlapping interactions. In general interactions of the interferon response pathway are in the top quarter of the map, with NF-κB directly below. Apoptosis is presented halfway down the map and toll-like receptor signalling is in the bottom quarter. 154 different protein or gene nodes are included in the pathway, along with 80 different complexes and 12 other molecular species (such as pathogens, DNA, RNA). The pathway diagram represents 272 different interactions.