Interactions between signalling modules. The 12 signalling modules identified by the PRODISTIN method are represented as circles. The lines between circles represent the 30 protein-protein interactions linking the signalling modules. The 16 blue lines and the 14 red lines correspond to protein-protein interactions linking different modules in the same pathway and in different pathways respectively. The INS2 module is disconnected from the other signalling modules since only direct interactions between modules are here represented.