Table 3 Summary of sensitivity analysis for the ARF model

× 2

× 10

× 2

× 10

p53 turnover

k_{synp 53}, k_{degp 53}

↓ (↑)

↓ (oscillations lost)

↑ (↓)

↑ (oscillations lost)

Mdm2 turnover

k_{synMdm 2}, k_{degMdm 2}

↓ (↑)

oscillations lost (↑)

↓ (↑)

oscillations lost (↓)

Mdm2_mRNA turnover

k _{synMdm 2mRNA}

k _{degMdm 2mRNA}

↓ (↑)

↓ (↑)

↓ (↑)

↓ (↑)

p53/Mdm2 binding and release

k_{binMdm 2p 53}, k_{relMdm 2p 53}

↔ (↔)

↔ (↔)

↓ (↑)

↓ (↑)

DNA damage

k _dam

↔ (↔)

↔ (↔) (Greater variability in period for ×10 increase)

↔ (↔)

↑ (↓) (Very few cells with oscillations for ×10 decrease)

DNA repair

k _repair

↔ (↔)

↔ (↔)

↓ (↑)

↓ (↑) (Very few cells with oscillations for ×10 increase)

ARF activation

k _actARF

↔ (↔)

↔ (↔)

↑ (↓)

↑ (↓) (Very few cells with oscillations for ×10 decrease)

ARF degradation

k _degARF

↔ (↔)

↔ (↔)

↔ (↔)

↓ (↑)

ARF/Mdm2 binding

k _{binARFMdm 2}

↔ (↔)

↔ (↔)

↔ (↓)

↔ (↓)

ARF-dependent Mdm2 degradation

k _{degARFMdm 2}

↔ (↔)

↔ (↔) (Period is very irregular in both cases)

↔ (↓)

↔ (↓)