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Table 3 Summary of sensitivity analysis for the ARF model

From: Explaining oscillations and variability in the p53-Mdm2 system

Biological process Parameters changed Effect on period as parameter is increased (decreased) Effect on amplitude as parameter is increased (decreased)
   × 2 × 10 × 2 × 10
p53 turnover ksynp 53, kdegp 53 ↓ (↑) ↓ (oscillations lost) ↑ (↓) ↑ (oscillations lost)
Mdm2 turnover ksynMdm 2, kdegMdm 2 ↓ (↑) oscillations lost (↑) ↓ (↑) oscillations lost (↓)
Mdm2_mRNA turnover k synMdm 2mRNA
k degMdm 2mRNA
↓ (↑) ↓ (↑) ↓ (↑) ↓ (↑)
p53/Mdm2 binding and release kbinMdm 2p 53, krelMdm 2p 53 ↔ (↔) ↔ (↔) ↓ (↑) ↓ (↑)
DNA damage k dam ↔ (↔) ↔ (↔) (Greater variability in period for ×10 increase) ↔ (↔) ↑ (↓) (Very few cells with oscillations for ×10 decrease)
DNA repair k repair ↔ (↔) ↔ (↔) ↓ (↑) ↓ (↑) (Very few cells with oscillations for ×10 increase)
ARF activation k actARF ↔ (↔) ↔ (↔) ↑ (↓) ↑ (↓) (Very few cells with oscillations for ×10 decrease)
ARF degradation k degARF ↔ (↔) ↔ (↔) ↔ (↔) ↓ (↑)
ARF/Mdm2 binding k binARFMdm 2 ↔ (↔) ↔ (↔) ↔ (↓) ↔ (↓)
ARF-dependent Mdm2 degradation k degARFMdm 2 ↔ (↔) ↔ (↔) (Period is very irregular in both cases) ↔ (↓) ↔ (↓)
  1. Key
  2. ↔ No change, ↓ Decrease in period or amplitude, ↑ Increase in period or amplitude