Figure 3

Corroborating evidence for the network alignment from gene position and molecular weight. a) The gene rank of reading frames of VZV is plotted against the rank in KSHV of their alignment partner. The points fall into two diagonal bands indicating the conservation of gene order between the two viruses. The ORF pairs aligned solely on the basis of matching interactions fall within those bands. The only significant deviation from those bands, the pair KSHV ORF28/VZV ORF65, has related sequences, see text. b) The molecular weights of aligned pairs of reading frames show a strong correlation (Pearson's correlation coefficient r = 0.94). The two exceptions again are aligned because they have related sequences (top left, indicated in green). The aligned ORFs with little or no sequence similarity (red circles, see text) show highly correlated molecular weights.