Figure 7
Tentative regulatory interactions inferred from protein expression and activation data for trastuzumab resistant HCC1954 cells. The heatmaps in Figure 6B were used to infer the interactions of proteins in the HCC1954 cell system with a probability higher than 50%. The numbers next to each arrow indicate the probability of each interaction. Solid black arrows denote the interactions (both direct and indirect) supported by published data, whereas dotted grey arrows denote novel interactions (compare with Figure 3). Normal arrows denote positive regulations, whereas blunt arrows denote negative regulations.