Figure 2

The efficacy to predict essential metabolic genes from centrality measures. The maximum Area Under the ROC Curve (max AUC) obtained from the Mann-Whitney test (see Methods) applied to the 18 different metabolic networks used in this study (see Table 1) are shown in the plot as black squares. Each square represent the max AUC obtained from groups of 1, 2, 3 or 4 centrality measures used to differentiate essential from non-essential genes. The vertical lines crossing each square represent the confidence interval at 99%.