Figure 4

Short timescale regulation. Short timescale regulation: ATP levels (left) and AcCoA levels (right) simulated using the same conditions as in Figure 3, presented here for days 80-83 (given also by hours) for the new model (black dashed curve), the old model [19] (blue curve), and experimental results (circles [24], squares [25], diamonds [26]). Due to improved regulation in the TCA cycle, energy homeostasis (constant ATP levels) is predicted more accurately in the new model (black dashed curve) compared to the old one (blue curve).