From: An evaluation of minimal cellular functions to sustain a bacterial cell
Classification1 | Â | Pathway map2 | E. coli | B. subtilis | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
General | Minor | Â | MPM3 | %4 | Exp5 | Com6 | Par7 | MPM3 | %4 | Exp5 | Com6 |
Metabolism | Carbohydrate | Glycolysis/Gluconeogenesis | OS | 59.5 | X | X | X | OS | 85.1 | X | X |
 |  | Citrate cycle (TCA cycle) | OS | 51.4 | X | X | X | OS | 28.2 | X | X |
 |  | Pentose phosphate pathway | OS | 100.0 | X | X | X | OS | 100.0 | X | X |
 |  | Pentose and glucuronate interconversions |  | 62.2 |  |  |  |  | 63.4 |  |  |
 |  | Fructose and mannose metabolism |  | 16.2 |  |  | X |  | 43.7 | X | X |
 |  | Galactose metabolism |  | 16.2 |  | X |  |  | 24.9 |  |  |
 |  | Ascorbate and aldarate metabolism |  | 21.6 |  |  |  |  | 10.1 |  |  |
 |  | Starch and sucrose metabolism |  | 32.4 |  |  | X |  | 18.0 |  | X |
 |  | Aminosugars metabolism | C |  | X | X | X | C |  | X | X |
 |  | Nucleotide sugars metabolism |  |  |  |  |  |  | 10.3 |  |  |
 |  | Pyruvate metabolism |  | 64.9 | X | X | X |  | 31.2 | X | X |
 |  | Glyoxylate and dicarboxylate metabolism | OS | 91.9 |  |  | X | OS | 92.9 |  | X |
 |  | Propanoate metabolism | OS | 94.6 | X | X | X |  | 92.5 | X | X |
 |  | C5-Branched dibasic acid metabolism | OS | 100.0 |  | X |  |  | 98.3 |  |  |
 |  | Butanoate metabolism |  | 35.1 |  |  | X |  | 30.3 |  | X |
 | Energy | Oxidative phosphorylation |  |  |  | X | X |  |  |  | X |
 |  | Carbon fixation | OS | 83.8 | X | X | X |  | 74.8 | X | X |
 |  | Reductive carboxylate cycle (CO2 fixation) |  | 56.8 |  | X |  |  | 45.9 |  | X |
 |  | Methane metabolism |  | 86.5 |  |  | X |  | 67.9 |  | X |
 |  | Nitrogen metabolism | OS | 97.3 |  |  |  | OS | 99.9 |  | X |
 |  | Sulfur metabolism | OS | 100.0 |  |  | X | OS | 99.2 |  | X |
 | Lipid | Fatty acid biosynthesis | C |  | X | X | X | C |  | X | X |
 |  | Fatty acid elongation in mitochondria |  | 24.3 |  |  |  |  | 4.9 |  |  |
 |  | Fatty acid metabolism | OS | 59.5 |  |  |  |  | 13.7 |  |  |
 |  | Synthesis and degradation of ketone bodies |  |  |  |  |  |  | 5.2 |  |  |
 |  | Biosynthesis of steroids |  | 5.4 | X | X | X | C |  | X |  |
 |  | Glycerolipid metabolism |  | 21.6 | X |  |  | OS | 100.0 |  |  |
 |  | Glycerophospholipid metabolism | OS | 100.0 | X | X |  | C |  | X |  |
 | Nucleotide | Purine metabolism | C |  | X | X | X | C |  | X | X |
 |  | Pyrimidine metabolism | C |  | X | X | X | C |  | X | X |
 | Amino Acid | Urea cycle and metabolism of amino groups | C |  |  | X | X | C |  |  |  |
 |  | Glutamate metabolism | C |  | X | X | X | C |  | X | X |
 |  | Alanine and aspartate metabolism | OS | 100.0 | X | X | X | C |  | X | X |
 |  | Glycine, serine and threonine metabolism | OS | 100.0 | X | X | X | OS | 99.8 | X | X |
 |  | Methionine metabolism | OS | 97.3 | X | X | X | OS | 98.3 | X | X |
 |  | Cysteine metabolism |  | 40.5 |  | X | X |  | 71.8 |  |  |
 |  | Valine, leucine and isoleucine degradation | OS | 100.0 |  |  | X | OS | 99.3 |  | X |
 |  | Valine, leucine and isoleucine biosynthesis | C |  | X | X | X | C |  | X | X |
 |  | Lysine biosynthesis | C |  | X | X | X | C |  | X | X |
 |  | Lysine degradation |  | 54.1 |  |  | X |  | 33.2 |  |  |
 |  | Arginine and proline metabolism | OS | 89.2 | X | X | X | C |  | X |  |
 |  | Histidine metabolism | C |  |  | X | X | C |  |  |  |
 |  | Tyrosine metabolism |  | 13.5 |  |  |  |  | 13.9 |  |  |
 |  | Phenylalanine metabolism |  | 67.6 |  |  |  |  | 12.5 |  |  |
 |  | Tryptophan metabolism |  | 24.3 |  |  | X |  | 21.0 |  | X |
 |  | Phenylalanine, tyrosine and tryptophan biosynthesis | C |  | X | X | X | C |  | X | X |
 | Other Amino Acids | beta-Alanine metabolism | OS | 100.0 |  |  | X |  | 76.8 |  |  |
 |  | Taurine and hypotaurine metabolism |  | 5.4 |  |  | X |  | 25.7 |  | X |
 |  | Selenoamino acid metabolism |  | 48.6 | X | X | X |  | 32.0 | X | X |
 |  | Cyanoamino acid metabolism |  | 75.7 |  |  |  | OS | 96.8 |  | X |
 |  | D-Glutamine and D-glutamate metabolism | OS | 67.6 | X | X | X | OS | 57.9 | X |  |
 |  | D-Alanine metabolism |  | 62.2 |  |  |  |  | 28.3 | X | X |
 |  | Glutathione metabolism | OS | 100.0 |  |  | X | OS | 60.8 |  | X |
 | Glycan | Lipopolysaccharide biosynthesis |  | 2.7 | X |  | X |  |  |  |  |
 |  | Peptidoglycan biosynthesis | C |  | X | X | X | C |  | X |  |
 |  | Polyunsaturated fatty acid biosynthesis |  | 70.3 |  |  |  |  | 36.3 |  |  |
 | Cofactors and Vitamins | Ubiquinone biosynthesis |  | 24.3 |  |  |  |  | 6.1 | X |  |
 |  | One carbon pool by folate | C |  | X | X | X | C |  | X | X |
 |  | Thiamine metabolism |  | 8.1 |  | X | X |  | 29.7 | X |  |
 |  | Riboflavin metabolism | C |  | X |  | X | C |  |  |  |
 |  | Vitamin B6 metabolism |  | 27.0 |  |  | X |  | 22.7 |  | X |
 |  | Nicotinate and nicotinamide metabolism | OS | 100.0 | X |  | X | OS | 100.0 | X |  |
 |  | Pantothenate and CoA biosynthesis | C |  | X | X | X | C |  | X | X |
 |  | Biotin metabolism | OS | 100.0 |  |  | X | OS | 98.1 |  |  |
 |  | Folate biosynthesis |  | 35.1 | X | X | X | C |  |  |  |
 |  | Porphyrin and chlorophyll metabolism | C |  | X | X | X | C |  |  |  |
 | Polyketides, Nonribosomal Peptides | Biosynthesis of siderophore group nonribosomal peptides |  | 27.0 |  |  |  |  | 6.8 |  |  |
 | Secondary Metabolites | Terpenoid biosynthesis |  |  | X |  | X | OS | 97.7 |  |  |
 |  | Alkaloid biosynthesis I |  | 16.2 |  |  |  |  | 4.2 |  |  |
 |  | Alkaloid biosynthesis II |  | 51.4 |  |  |  |  |  |  |  |
 |  | Novobiocin biosynthesis |  | 27.0 |  |  |  |  | 4.5 |  |  |
 |  | Streptomycin biosynthesis |  | 5.4 |  |  |  |  | 26.8 |  |  |
 | Xenobiotics | Caprolactam degradation |  | 10.8 |  |  |  |  |  |  |  |
 |  | Biphenyl degradation |  | 27.0 |  |  |  |  |  |  |  |
 |  | Toluene and xylene degradation |  | 18.9 |  |  |  |  |  |  |  |
 |  | 3-Chloroacrylic acid degradation |  |  |  |  |  |  | 3.7 |  |  |
 |  | Styrene degradation |  | 18.9 |  |  |  |  |  |  |  |
 |  | 1,4-Dichlorobenzene degradation |  | 27.0 |  |  |  |  |  |  |  |
 |  | Ethylbenzene degradation |  | 27.0 |  |  |  |  |  |  |  |
 |  | Fluorene degradation |  | 27.0 |  |  |  |  |  |  |  |
 |  | Carbazole degradation |  | 16.2 |  |  |  |  |  |  |  |
 |  | Benzoate degradation via CoA ligation |  | 18.9 |  |  |  |  | 15.8 |  |  |
 |  | Benzoate degradation via hydroxylation |  | 24.3 |  |  |  |  |  |  |  |
Genetic Information Processing | Transcription | RNA polymerase | C | Â | X | X | X | C | Â | X | X |
 | Translation | Aminoacyl-tRNA biosynthesis | C |  | X | X | X | C |  | X | X |
 |  | Ribosome | C |  | X | X | X | C |  | X | X |
 | Folding, Sorting, Degradation | Protein export | C |  | X | X | X | C |  | X | X |
 | Replication and Repair | DNA polymerase | C |  | X | X | X | C |  | X | X |
Environmental Information Processing | Membrane Transport | ABC transporters - General | Â | Â | X | X | X | Â | Â | X | X |
 |  | Phosphotransferase system (PTS) |  |  |  |  | X |  |  |  | X |
 | Signal Transduction | Two-component system - General |  |  |  | X | X |  |  | X | X |
Cellular Processes | Cell Motility | Bacterial chemotaxis - General | Â | Â | Â | Â | X | Â | Â | Â | X |
 |  | Flagellar assembly |  |  |  |  | X |  |  |  | X |