Figure 7
From: Dynamic simulations on the mitochondrial fatty acid Beta-oxidation network
Simulated production of acetyl-CoA during fasting. Relative production rate of acetyl-CoA as a function of time following a 20% and 40% increase of palmitoyl-CoA (C16) concentration. After 4 hours the production rate of acetyl-CoA of healthy controls reached its maximum. In the case of simulating MCAD deficiency, the production rate of acetyl-CoA is still 50% below its maximum after 4 hours; whereas simulations of the LCAD deficiency showed a very low production rate of acetyl-CoA even after 40 hours – reaching about 10% of the production rate of healthy controls.