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Table 1 Protein evolutionary rates distribution along the signaling information flow

From: Protein evolution on a human signaling network

Cellular location Extracellular Membrane Cytoplasm Nucleus
dN/dS (median) 0.220 0.108 0.086 0.094
P value* 1.36 × 10-5 0.01 0.04 0.13
  1. *The P values were calculated by Wilcoxon test by comparing the protein evolutionary rates in each group with the evolutionary rates of the whole network proteins.