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Table 2 Top pathways enriched using genetic association research or environmental factor research.

From: Genetic and environmental pathways to complex diseases

Top 15 pathways enriched using phenotype-gene research compiled in the Genetic Association Database
Pathway Name KEGG pathway ID Number of diseases significantly enriched for pathway Number of environmental factors significantly enriched for pathway
Antigen processing and presentation path:hsa04612 59 57
Metabolism of xenobiotics by cytochrome P450 path:hsa00980 49 421
Hematopoietic cell lineage path:hsa04640 40 52
Renin-angiotensin system path:hsa04614 28 29
Retinol metabolism path:hsa00830 27 659
Natural killer cell mediated cytotoxicity path:hsa04650 26 97
Neuroactive ligand-receptor interaction path:hsa04080 24 30
Tyrosine metabolism path:hsa00350 23 28
Jak-STAT signaling pathway path:hsa04630 20 104
Complement and coagulation cascades path:hsa04610 16 24
Linoleic acid metabolism path:hsa00591 15 97
Cytokine-cytokine receptor interaction path:hsa04060 15 63
Adipocytokine signaling pathway path:hsa04920 15 185
T cell receptor signaling pathway path:hsa04660 13 38
Toll-like receptor signaling pathway path:hsa04620 12 114
Top 15 pathways enriched using environmental factor-gene research compiled in the Comparative Toxicogenomics Database
Pathway Name KEGG pathway ID Number of diseases significantly enriched for pathway Number of environmental factors significantly enriched for pathway
Retinol metabolism path:hsa00830 27 659
Apoptosis path:hsa04210 11 457
Metabolism of xenobiotics by cytochrome P450 path:hsa00980 49 421
gamma-Hexachlorocyclohexane degradation path:hsa00361 7 224
Androgen and estrogen metabolism path:hsa00150 5 194
PPAR signaling pathway path:hsa03320 11 189
Adipocytokine signaling pathway path:hsa04920 15 185
p53 signaling pathway path:hsa04115 7 160
Toll-like receptor signaling pathway path:hsa04620 12 114
Focal adhesion path:hsa04510 5 114
Cell cycle path:hsa04110 2 113
Pentose and glucuronate interconversions path:hsa00040 2 106
Jak-STAT signaling pathway path:hsa04630 20 104
Fc epsilon RI signaling pathway path:hsa04664 6 104
GnRH signaling pathway path:hsa04912 1 100