The Hes1 oscillator. (a) Two-parameter K1-n1 bifurcation diagram for the Hes1 oscillator. (b) Close-in of the bifurcation diagram with Zeiser et al.'s point highlighted in red. (c) Temporal revolution of Hes1 nuclear concentration (p2) for three feedback strengths: K1 = 10 (black, solid); K1 = 0.1 (blue, dot) and K1 = 100 (red, dash).