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Table 4 Major intercompartmental protein interactions in yeasta.

From: Calculation of the relative metastabilities of proteins in subcellular compartments of Saccharomyces cerevisiae

Interaction log Interaction log
actin-bud 0.262 -74.9 vacuole-bud 0.384 -75.3
actin-bud.neck 0.078 -83.5 vacuole-cell periphery 0.305 -75.7
actin-cell periphery 0.183 -75.3 vacuole-cytoplasm 0.188 -73.4
actin-endosome 0.129 -75.6 vacuole-endosome 0.251 -75.9
actin-vacuolar membrane 0.081 -73.3 vacuole-late Golgi 0.358 -75.4
actin-mitochondrion 0.049 -64.2 nucleus-actin -0.039 -74.3
actin-microtubule 0.123 -78.3 nucleus-microtubule 0.084 -80.1
microtubule-bud 0.139 -71.8 nucleus-spindle pole 0.014 -82.3
microtubule-bud neck -0.045 -69.3 nucleus-bud 0.223 -74.9
microtubule-cell periphery 0.060 -69.3 nucleus-bud neck 0.039 -92.5
microtubule-cytoplasm -0.057 -89.8 nucleus-cytoplasm 0.027 -59.7
microtubule-spindle pole -0.070 -79.7 nucleus-nucleolus -0.031 -70.0
spindle.pole-cytoplasm 0.013 -35.1 nuclear periphery-bud neck -0.081 -69.4
spindle.pole-nuclear periphery 0.106 -76.3 nuclear periphery-cytoplasm -0.093 -82.0
ER-cell.periphery 0.142 -82.3 nuclear periphery-nucleus -0.120 -77.0
ER-cytoplasm 0.025 -96.5 nuclear periphery-nucleolus -0.152 -75.5
ER-early Golgi 0.259 -78.0 peroxisome-cell periphery 0.064 -78.7
ER-nuclear.periphery 0.118 -85.0 peroxisome-cytoplasm -0.053 -80.0
ER-peroxisome 0.078 -85.3 peroxisome-lipid particle 0.140 -74.9
Golgi-endosome -0.205 -75.9 peroxisome-mitochondrion -0.071 -80.0
Golgi-vacuole -0.456 -75.9 mitochondrion-cell periphery 0.135 -79.4
Golgi-late Golgi -0.097 -77.5 mitochondrion-cytoplasm 0.017 -79.9
Golgi-early Golgi -0.034 -89.0 mitochondrion-nucleus -0.010 -23.6
  1. a. Interactions between proteins in different subcellular locations in S. cerevisiae were identified in the literature. The calculated reaction coefficients on O2(g)and the metastable equilibrium value of log were calculated for each reaction between reference model proteins. Names of locations shown in bold indicate that the model value of log for this compartment (Table 3) lies in the metastability range for the reference model protein in the particular reaction.