Validation of our Method. Schematic representation of the approach we use to evaluate the heuristic we propose. The topology of a given GRN is inferred from in-vivo data (red arrow). To judge this step, we propose our heuristic as described in text and Figure 2 (yellow arrow). The comparison of in-vivo data and detected TPEs yields some measure of matching effects (left light blue arrow). In order to evaluate this, we simulate in-silico data that perfectly matches an underlying topology (green arrow). Comparison between in-silico data and detected TPEs indicates the reliability of the heuristic (lower light blue arrow).