Figure 5

Biological subnetworks exhibiting significant increases in entropy. We contrast the integrated PIN-mRNA metastatic and non-metastatic networks for four nodes/genes exhibiting significant increases in entropy and related to tumour suppressor pathways and cancer hallmarks: MYBL2 and cell-cycle, IGFBP7 and IGF-signalling, IL2RB and IL2 immune-mediated tumour suppression, BCL2 and apoptosis. In each case, we only depict the nearest neighbors (interacting protein partners) of the selected nodes. The edge color shows the strength of the Pearson correlation C in expression between the two genes across the given phenotype: bright red (0.5 <C < 1), dark red (0.25 <C < 0.5), grey (-0.25 <C < 0.25), dark green (-0.5 <C < -0.25), bright green (-1 <C < -0.5).