Interaction network associations of regional metagenes. A) Overview of the interaction network defined by the proliferation metagenes and RMGs 1 to 7 (8q13-22, 8p12-22, 11q13, 7p15, 3p14-21, 16p13, 17p11-13 respectively). Light gray edges, protein-protein interactions, red lines, transcriptional interactions, blue lines, interactions within protein complexes. Genes from RMGs 8 to 42 participating in signalling within the network core are shown in magenta. Direct interactions between the proliferation metagenes and top seven RMGs gene members are emphasized in bold. B) Close association in proliferation metagenes gene targets between RMG 2 (8p12-22) and RMG 17 (23q22). Proliferation metagenes genes targeted only by RMG 2 are shown in green, those targeted only by RMG 17 are shown in salmon pink and those targeted by both RMGs are highlighted in yellow.