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Table 2 Analysis of interconnected groups (pathways) within the list of genes differentially expressed between adult and newborn Weddell seals.

From: Transformation of metabolism with age and lifestyle in Antarctic seals: a case study of systems biology approach to cross-species microarray experiment

N Network GO Processes Total nodes Root nodes p-Value
1 MLC2, MEF2C, Fibrillin 1, Beta-catenin, VEGF-A, NCOA6 (TRBP) heart development (18.9%; 2.656e-35), organ development (39.3%; 5.404e-24), anatomical structure morphogenesis (30.4%; 3.790e-22), system development (43.2%; 4.958e-21), developmental process (50.0%; 2.940e-20) 291 6 0
2 NLK, TCF7L2 (TCF4), Beta-catenin, ITF2, VEGF-A, Calmodulin cellular macromolecule metabolic process (60.5%; 9.000e-22), translational elongation (8.3%; 1.114e-21), macromolecule metabolic process (62.2%; 8.712e-19), cellular metabolic process (69.1%; 1.001e-18), translation (10.8%; 3.135e-15) 392 6 0
3 RanBPM, Tubulin alpha, CLIP170, Tubulin (in microtubules) mitotic cell cycle (76.7%; 6.661e-30), M phase (73.3%; 2.818e-29), mitosis (63.3%; 2.117e-27), nuclear division (63.3%; 2.117e-27), M phase of mitotic cell cycle (63.3%; 3.441e-27) 30 4 7.09E-05
4 Karyopherin beta 1, Tubulin alpha, CLIP170, Tubulin (in microtubules) mitotic cell cycle (76.7%; 6.661e-30), M phase (73.3%; 2.818e-29), cell cycle phase (73.3%; 2.038e-26), cell cycle process (76.7%; 9.582e-26), mitosis (60.0%; 2.193e-25) 30 4 7.09E-05
5 COL1A1, Jagged1, HEY1, G-protein alpha-s translational elongation (10.6%; 4.189e-19), skeletal system development (16.5%; 1.262e-18), embryonic development (22.0%; 4.330e-18), organ morphogenesis (24.3%; 8.874e-18), anatomical structure morphogenesis (30.3%; 2.059e-17) 232 4 0
6 NCOA6 (TRBP), Fibrillin 1, VEGF-A, MLC2 heart development (14.0%; 3.117e-22), translational elongation (9.2%; 8.528e-21), cellular macromolecule metabolic process (59.2%; 3.169e-16), cellular metabolic process (68.5%; 1.129e-14), organ development (32.5%; 1.235e-14) 304 4 0
7 DDX5, Beta-catenin, Collagen III, ZO-1 translational elongation (8.1%; 2.264e-21), cellular macromolecule metabolic process (59.3%; 2.424e-20), cellular metabolic process (69.3%; 1.710e-19), macromolecule metabolic process (60.6%; 5.544e-17), translation (10.8%; 1.321e-15) 396 4 0
8 KIF5B, Tubulin alpha, Tubulin (in microtubules) microtubule-based movement (58.3%; 1.474e-12), microtubule-based process (66.7%; 5.924e-12), cytoskeleton-dependent intracellular transport (50.0%; 6.967e-12), intermediate filament-based process (41.7%; 2.715e-11), microtubule-based transport (41.7%; 4.662e-11) 12 3 8.55E-05
9 PYGM, IRS-2, G-protein alpha-s energy reserve metabolic process (23.3%; 1.472e-15), protein amino acid phosphorylation (44.2%; 2.100e-14), phosphorylation (46.5%; 4.698e-14), phosphate metabolic process (48.8%; 1.036e-13), phosphorus metabolic process (48.8%; 1.053e-13) 53 3 4.87E-17
10 Nucleophosmin, Jagged1, VEGF-A cellular metabolic process (72.2%; 1.602e-08), RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (9.6%; 3.962e-08), nuclear mRNA splicing, via spliceosome (9.6%; 3.962e-08), cellular macromolecule metabolic process (60.9%; 4.590e-08), RNA splicing, via transesterification reactions (9.6%; 5.227e-08) 121 3 1.8E-223