Figure 1

Schematic of analyses carried out in this study. This illustrates the flowchart of analysis performed in this study. R1 and R2 refer to region 1 and region 2, respectively. Differentially expressed (DE) genes were identified by comparing AD affected to normal controls within each region. When pairs of regions were compared, the coexpression network was built using the common (intersection) DE genes between the regions. Genes with no topological overlap between the coexpression networks were taken for further analyses.