Figure 8
From: Dynamic functional modules in co-expressed protein interaction networks of dilated cardiomyopathy
Flow diagram of the proposed integrative network analysis procedure. Flow diagram of discovery DCM related modules from static PIN by integrating gene expression profiles. In static PIN, each PPI was assigned a correlation derived from Pearson correlation coefficient between paired genes engaged in a PPI. Then, CePPIs and PPIs with significant correlations were utilized to construct the CePINs which were extracted from the static PIN. Next, gene sets which are provided with significant functional enrichment in GO annotation categories were grouped and isolated from CePINs. Finally, functional subnetworks which were only involved in DCM CePIN were treated as candidate DCM related modules. In addition, only candidate DCM related modules with GO annotations of levels ≥ 5 were considered as DCM related modules.