Figure 2
From: Patterns of human gene expression variance show strong associations with signaling network hierarchy
Functional significance of Expression Variance of human genes. A) Boxplots of EVexpo values of genes in the classes of genes as defined in Kim et al (2005) [8]. Class I of genes have RNA Polymerase PIC occupancy and active transcription, Class II has PIC occupancy but no active transcription, Class III have no or low (transient) PIC occupancy but active transcription, Class IV have no detectable PIC occupancy or transcription (see Kim et al (2005)). P-values of difference were calculated using Wilcoxon rank sum test. B) Heatmaps of interaction densities between low and high EVexpo genes based on functional relations. Each square i,j represents density of interactions between bins i and j as defined by number of interactions between bins i and j divided by total number of interactions of bins i and j in the network. C) Pie charts of most significantly enriched GO categories in 500 highest and lowest EVexpo genes. Significance of enrichment was assessed by hypergeometric distribution (P < 10-5). Only GO categories with more than 5 annotated genes were selected.