Table 4 False negative (FN) predictions that could not be corrected by our network modifications.
From: Development and analysis of an in vivo-compatible metabolic network of Mycobacterium tuberculosis
Gene Locus | Gene Name | Pathway | Function/Reaction | Reasons Why Network Modification Could Not Be Made |
|---|---|---|---|---|
Rv1304 | atpB | Purine metabolism | Synthesis of ATP | The product of this gene catalyzes the reaction together with that of the TN gene atpH |
Rv2391 | nirA | Vitamin and cofactor metabolism | Reduction of nitrite | The product of this gene catalyzes the reaction together with that of the TN gene nirB |
Rv3758c | proV | Transport | Transport of choline, L-carnitine, glycine betaine, and proline | The product of this gene catalyzes the transport of choline, L-carnitine, glycine betaine, and proline together with the TN genes proZ, proW, and proX |
Rv2502c | accD1 | Sugar metabolism | Convert propionyl-CoA into S-methylmalonyl-CoA | The product of this gene catalyzes the reaction together with the TN gene accA2 |
Rv2072c | cobL | Porphyrin metabolism | Production of S-adenosyl-L-homocysteine | The product of this gene catalyzes the synthesis of cobalamin together with the TN genes cobK, cobM, cobH, cobN, cobI, and cobG |
Rv3534c | Rv3534c | Pyruvate metabolism | Convert 4-hydroxy-2-oxopentanoate into pyruvate | In a pathway without any synthesis or uptake reaction for the metabolite 4-hydroxy-2-oxopentanoate |
Rv2241 | aceE | Glycolysis/gluconeogenesis | Convert pyruvate into acetyl-CoA | Unable to determine the reason |