Performance envelopes and therapeutic fitting. (A) Temporal simulation of the nonlinear model in Figure 2B with nominal parameters, under healthy conditions (u
= 0.2, and initial conditions given by the healthy steady-state), and diseased conditions (u
= 2, and initial conditions given by the diseased steady-state). Performance envelopes are generated to contain the stochastic envelopes, resulted by the Stochastic Simulation Algorithm (mean ± standard deviation). Nominal results are also shown in dashed lines. (B) Comparison between the performance envelopes and the results obtained from the nonlinear model, starting from the diseased steady-state, with parameter values modified according to the 56 therapies (blue curves).