Figure 3
From: Improving the iMM904 S. cerevisiae metabolic model using essentiality and synthetic lethality data
Resolution of a GSL through reaction suppressions. (A) FUR1 and URA3 form a GSL since based on the i MM904 model there exists alternative pathways for producing the biomass precursor ump in the absence of these genes. (B) By suppressing (or removing) the reaction PYNP2r, all the production routes towards the biomass precursor ump is blocked, rendering the simultaneous deletion of FUR1 and URA3 lethal.