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Table 3 Spearman correlation and partial Spearman correlation of PPID and ePPID with protein evolutionary rate.

From: Understanding protein evolutionary rate by integrating gene co-expression with protein interactions

Protein interaction datasets n PPID vs. dN PPID vs. dN control for abundance ePPID vs. dN ePPID vs. dN control for abundance
   rho (p) rho (p) rho (p) rho (p)
Y2H-union 793 -0.0249(4.85e-01) -0.0260(4.64e-01) -0.116(1.06e-03) -0.0930(8.66e-03)
Combined-AP/MS 763 -0.135(1.85e-04) -0.0666(6.59e-02) -0.229(1.51e-10) -0.103(4.35e-03)
LC-multiple 680 -0.149(9.75e-05) -0.134(4.16e-04) -0.260(6.16e-12) -0.179(2.14e-06)
Updated-HC 1,587 -0.140(2.27e-08) -0.0992(7.24e-05) -0.208(5.21e-17) -0.121(1.14e-06)
DIP-CORE 968 -0.108(7.72e-04) -0.0679(3.45e-02) -0.214(1.72e-11) -0.110(5.65e-04)
DIP-FULL 1,792 -0.223(1.24e-21) -0.162(3.31e-12) -0.252(2.77e-27) -0.156(2.69e-11)
  1. dN represents protein evolutionary rate measured by non-synonymous substitutions. n is the number of proteins for which PPID, protein evolutionary rate and abundance data are all available. rho is Spearman rank correlation coefficient, and p is the corresponding statistical significance. Bold indicates that p is significant at the statistical significance level of 0.05.