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Figure 4 | BMC Systems Biology

Figure 4

From: The protein kinase Mζ network as a bistable switch to store neuronal memory

Figure 4

Bifurcation analyses. A) Bifurcation diagram with respect to the PKMζ synthesis rate, j 1 . B) Bifurcation analysis with respect to the PKMζ-independent actin polymerization rate, j 2 . Only one (SN1) of the two saddle node bifurcations is seen in this plot. C, D) Two-parameter bifurcation analysis with respect to j 2 , and the PKMζ-dependent actin polymerization rate, j 3 . C) A two-dimensional plot with j 2 in the X-axis and j 3 in the Y-axis. D) A three-dimensional plot with j 2 in the X-axis, j 3 in the Y-axis, and steady-state [PKMζ] in the Z-axis (log scale). E) Bifurcation analysis with respect to j 4 , the rate at which PKMζ mRNA is incorporated into the translational machinery. In panels A, B, and E, the solid and dashed lines indicate [PKMζ] at stable and unstable steady states, respectively; the circles denote saddle-node bifurcations. In panels C and D, the solid lines, solid circles, and open circle (only in panel C) indicate saddle-node bifurcations (SN1 and SN2), the cusp bifurcation point, and the default values of j 1 and j 2 , respectively.

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