Compound
|
phospho-MK2
|
phospho-ATF2
|
substrate selectivity*
|
---|
SD-0006 | 0.11 ± 1.2 | 0.35 ± 1.1 | 3.3 |
BIRB 796 | 7.75 ± 1.3 | 0.92 ± 1.1 | 0.12 |
CMPD1 | 23.4 ± 1.9 | >400** | >17 |
- IC50's are shown ± standard error.
- *Substrate Selectivity is defined as a relative measure between inhibiting phospho-ATF2 and phospho-MK2 = (ATF2 IC50)/(MK2 IC50). This quantity is distinct and separable from a compound's potency.
- **CMPD1 is unable to completely inhibit phospho-ATF2 within its solubility limits.