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Table 1 Mapping capability of the DARPP-32 system between neuronal signals and phosphorylation profiles of PKA and PP1

From: The internal state of medium spiny neurons varies in response to different input signals

Input Signal DARPP-32 Status Output
Dopaminea Glutamatea Thr34b Thr75b75 PKAb PP1b
Any signal of
millisecond to second scale
  Δ≡ Δ≡
  ms-sp-tt-ha Δ↑
  ms-sp-tt-la Δ≡ Δ≡
  ms-sp-st-ha Δ≡ Δ≡
  ms-sp-st-la ↔≡ Δ≡
  ms-rp-tt-ha Δ↑
  ms-rp-tt-la Δ≡ Δ≡
  ms-rp-st-ha/la Δ≡ Δ≡
  s-sp-tt-ha Δ≡ Δ≡
  s-sp-tt-la ↔≡ ↔≡
  s-sp-st-ha Δ≡ Δ≡
  s-sp-st-la ↔≡ ↔≡ Δ≡
  s-rp-tt-ha/la Δ≡ Δ≡
  s-rp-st-ha Δ≡ Δ≡
  s-rp-st-la Δ≡ ↔≡ Δ≡
ms-sp-tt-ha ms-sp-tt-ha Δ↑
ms-sp-tt-la ms-sp-tt-la Δ≡ Δ≡
ms-sp-st-ha/la ms-sp-st-ha/la Δ≡ Δ≡
ms-rp-tt-ha ms-rp-tt-ha Δ↑
ms-rp-tt-la ms-rp-tt-la Δ≡ Δ≡
ms-rp-st-ha/la ms-rp-st-ha/la Δ≡ Δ≡
s-sp-tt-ha s-sp-tt-ha Δ≡ Δ≡
s-sp-tt-la s-sp-tt-la Δ≡ Δ≡
s-sp-st-ha/la s-sp-st-ha/la Δ≡ Δ≡
s-rp-tt-ha/la s-rp-tt-ha/la Δ≡ Δ≡
s-rp-st-ha/la s-rp-st-ha/la Δ≡ Δ≡
  1. a: Abbreviations for neurotransmission patterns are: millisecond (ms), second (s), a single pulse (sp), repetitive pulses (rp), transient transmission (tt), sustained transmission (st), high amplitude signal (ha), and low amplitude signal (la).
  2. b: The responses of the DARPP-32 state and its output are presented as transient dynamics and long-term state. The transient dynamics is described as trough (), essentially flat (↔, and peak (Δ) reflecting the main characteristic of the response. The long-term state of phosphorylation is given in relation to the resting level as decreased (↓), basal (≡), and increased (↑).