From: The internal state of medium spiny neurons varies in response to different input signals
Input Signal | DARPP-32 Status | Output | |||
---|---|---|---|---|---|
Dopaminea | Glutamatea | Thr34b | Thr75b75 | PKAb | PP1b |
Any signal of millisecond to second scale | Δ≡ | ∇≡ | Δ≡ | ∇≡ | |
ms-sp-tt-ha | ∇↓ | ∇↓ | ∇↓ | Δ↑ | |
ms-sp-tt-la | ∇≡ | ∇≡ | Δ≡ | Δ≡ | |
ms-sp-st-ha | ∇≡ | ∇≡ | Δ≡ | Δ≡ | |
ms-sp-st-la | ∇≡ | ∇≡ | ↔≡ | Δ≡ | |
ms-rp-tt-ha | ∇↓ | ∇↓ | ∇↓ | Δ↑ | |
ms-rp-tt-la | ∇≡ | ∇≡ | Δ≡ | Δ≡ | |
ms-rp-st-ha/la | ∇≡ | ∇≡ | Δ≡ | Δ≡ | |
s-sp-tt-ha | ∇≡ | ∇≡ | Δ≡ | Δ≡ | |
s-sp-tt-la | ∇≡ | ∇≡ | ↔≡ | ↔≡ | |
s-sp-st-ha | ∇≡ | ∇≡ | Δ≡ | Δ≡ | |
s-sp-st-la | ∇≡ | ↔≡ | ↔≡ | Δ≡ | |
s-rp-tt-ha/la | ∇≡ | ∇≡ | Δ≡ | Δ≡ | |
s-rp-st-ha | ∇≡ | ∇≡ | Δ≡ | Δ≡ | |
s-rp-st-la | ∇≡ | Δ≡ | ↔≡ | Δ≡ | |
ms-sp-tt-ha | ms-sp-tt-ha | ∇↓ | ∇↓ | ∇↓ | Δ↑ |
ms-sp-tt-la | ms-sp-tt-la | ∇≡ | ∇≡ | Δ≡ | Δ≡ |
ms-sp-st-ha/la | ms-sp-st-ha/la | ∇≡ | ∇≡ | Δ≡ | Δ≡ |
ms-rp-tt-ha | ms-rp-tt-ha | ∇↓ | ∇↓ | ∇↓ | Δ↑ |
ms-rp-tt-la | ms-rp-tt-la | ∇≡ | ∇≡ | Δ≡ | Δ≡ |
ms-rp-st-ha/la | ms-rp-st-ha/la | ∇≡ | ∇≡ | Δ≡ | Δ≡ |
s-sp-tt-ha | s-sp-tt-ha | ∇≡ | ∇≡ | Δ≡ | Δ≡ |
s-sp-tt-la | s-sp-tt-la | Δ≡ | ∇≡ | Δ≡ | ∇≡ |
s-sp-st-ha/la | s-sp-st-ha/la | Δ≡ | ∇≡ | Δ≡ | ∇≡ |
s-rp-tt-ha/la | s-rp-tt-ha/la | ∇≡ | ∇≡ | Δ≡ | Δ≡ |
s-rp-st-ha/la | s-rp-st-ha/la | ∇≡ | ∇≡ | Δ≡ | Δ≡ |