While this paper was in revision Goula et al. (PLoS Genet. 2009 December; 5(12): e100074)ublished findings in which they showed that the stoichiometry of base excision repair (BER) roteins differed in striatum compared to cerebellum in an HD fragment mouse odel. It would therefore be of interest to determine whether these findings extend to a roader correlation between tissue instability and BER protein stoichiometry across a wide range of tissues.
Note added in proof
15 April 2010
While this paper was in revision Goula et al. (PLoS Genet. 2009 December; 5(12): e100074)ublished findings in which they showed that the stoichiometry of base excision repair (BER) roteins differed in striatum compared to cerebellum in an HD fragment mouse odel. It would therefore be of interest to determine whether these findings extend to a roader correlation between tissue instability and BER protein stoichiometry across a wide range of tissues.
Competing interests
None declared