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Table 2 Pathways significantly correlated with the instability index.

From: A novel approach to investigate tissue-specific trinucleotide repeat instability

Name Size NES P value
Negative correlation    
G1 to S cell cycle reactome 150 -1.87 0.0000
Nuclear membrane 208 -1.72 0.0023
Negative regulation of progression through cell cycle 183 -1.64 0.0024
Mitosis 261 -1.82 0.0044
M phase of mitotic cell cycle 262 -1.81 0.0044
Protein kinase inhibitor activity 41 -1.71 0.0046
G1 pathway 68 -1.85 0.0046
Cell cycle pathway 57 -1.85 0.0066
Mitotic cell cycle 427 -1.76 0.0069
Kinase inhibitor activity 42 -1.72 0.0070
Protein amino acid-ribosylation 30 -1.92 0.0071
Eicosanoid synthesis 29 -1.79 0.0072
P53 pathway 43 -1.77 0.0085
Notch pathway 17 -1.70 0.0086
Cell cycle 176 -1.82 0.0087
Integrin mediated cell adhesion 222 -1.73 0.0089
RNA helicase activity 41 -1.78 0.0097
Positive correlation    
UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity 21 1.84 0.0000
Adrenoceptor activity 25 1.94 0.0017
Amine receptor activity 47 1.88 0.0018
Beta-1,3-galactosyltransferase activity 25 1.94 0.0020
Mono amine GPCRS 45 1.88 0.0038
Glutamate metabolism 51 1.78 0.0042
Neuromuscular junction development 15 1.76 0.0057
Serotonin receptor activity 22 1.81 0.0057
Oxidoreductase activity, acting on the CH-CH groups of donors, oxygen as acceptor 15 1.72 0.0064
  1. Gene set enrichment analysis was performed using Pearson correlation between expression level and instability index as a ranking metric. Significant gene sets were identified by permutation-based nominal p value (p < 0.01). NES, normalized enrichment score.