Network analysis of proteins required for survival after MMS damage. A) Subnetwork of proteins required for survival after treatment with the DNA damaging agent MMS in fly, before (left) and after (right) PPI prediction. Nodes in black are connected before prediction, while nodes in red are orphans before prediction. Yellow nodes are added to the interactome after interologue prediction. Blue edges are interactions known in fly, while black edges are predicted interactions. B) Global efficiency of the subnetworks before (left) and after (right) interologue prediction (dashed red line). The global efficiency of random networks determined by a set of random nodes equal to the number of nodes used in the actual set are shown with blue bars.