Predicted interactors of proteasome components that affect its activity. A) Subnetwork of proteasome components (black circles) and interactors (white squares) that affect proteasome activity in fly. Thick black edges are known PPI, while grey edges are predicted PPI. B) Proteasome activity normalized per cell after knock down of proteins indicated in A. Luc (non-targeting RNAi against luciferase) and Rpn2 as negative and positive controls, respectively). Error bars represent the standard deviation of four replicates, and p-values are given above each bar.