An integrated machine learning approach for predicting DosR-regulated genes in Mycobacterium tuberculosis

BMC Systems Biology

Table 3 Top ranking potentially DosR-regulated genes.

Rv acc.	description	gene name
Rv0079**	hypothetical protein
Rv0311*	possible remnant of A transposase
Rv0482*	UDP-N-acetylenolpyruvoylglucosamine reductase	murB
Rv0569**	hypothetical protein
Rv0571c**	hypothetical protein
Rv0574c**	poly-gamma-glutamate synthesis protein
Rv0654*	putative dioxygenase
Rv0835*	possible lipoprotein LpqQ	ipqQ
Rv0946c*	glucose-6-phosphate isomerase	pgi
Rv1371*	probable conserved membrane protein
Rv1733c**	probable conserved transmembrane protein
Rv1737c**	MFS transporter, NNP family, nitrate transporter	nark2
Rv1738**	hypothetical protein
Rv1813c**	hypothetical protein
Rv1954c*	hypothetical protein
Rv1997**	cation-transporting ATPase	ctpF
Rv1998c*	hypothetical protein
Rv2005c**	hypothetical protein
Rv2006**	putative trehalose/maltose hydrolase	otsB1
Rv2007c**	ferredoxin	fdxA
Rv2031c**	heat shock protein hspx	hspX
Rv2032**	Conserved hypothetical protein Acg	acg
Rv2623	hypothetical protein	TB31.7
Rv2625c	probable conserved transmembrane alanine and leucine rich protein
Rv2626c**	hypothetical protein
Rv2627c**	hypothetical protein
Rv2628**	hypothetical protein
Rv2629	hypothetical protein
Rv3044*	putative iron (III) dicitrate transport system substrate-binding protein	fecB
Rv3081*	hypothetical protein
Rv3127**	hypothetical protein
Rv3130c**	hypothetical protein
Rv3131**	hypothetical protein
Rv3134c**	hypothetical protein

The 34 top ranking genes according to the logistic score. Genes with one * are the novel DosR-regulated genes detected in this study, while those with two * are the documented DosR-regulated genes in the training data. Genes with no * were previously reported as indirectly regulated by DosR, but were found to contain DosR-binding-motifs in this study.

ISSN: 1752-0509