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Table 3 The enriched pathways of the responsive gene modules of VEGF stimulated HUVECs identified by different methods.

From: Identification of responsive gene modules by network-based gene clustering and extending: application to inflammation and angiogenesis

Pathway

ClustEx

Meet/Min (z-score)

jActiveModules

Meet/Min (z-score)

GXNA

Meet/Min (z-score)

FoldChange_2.0

Meet/Min (z-score)

Chronic myeloid leukemia

0.25(6.20), 1 a

0.19(5.32), 2

0.07(0.72), 4

0.19(3.67), 3

TGF-beta signaling pathway

0.23(5.88), 1

0.14(3.40), 2

0.04(-0.53), 4

0.14(2.20), 3

Adherens junction

0.22(4.74), 1

0.10(1.73), 3

0.12(2.50), 2

0.12(1.23), 4

Pancreatic cancer

0.19(3.99), 2

0.18(4.76), 1

0.06(0.13), 4

0.17(2.76), 3

Neurodegenerative Diseases

0.24(3.75), 1

0.12(1.57), 2

0.03(-0.61), 4

0.12(0.81), 3

Focal adhesion

0.13(3.66), 1

0.08(1.72), 2

0.07(1.16), 4

0.11(1.71), 3

Cell cycle

0.16(3.51), 2

0.16(5.02), 1

0.01(-1.89), 4

0.05(-1.27), 3

Long-term potentiation

0.19(3.47), 1

0.10(1.52), 2

0.05(-0.05), 4

0.08(0.13), 3

Wnt signaling pathway

0.14(3.24), 1

0.06(0.35), 2

0.04(-0.74), 3

0.05(-1.03), 4

Prostate cancer

0.16(3.15), 2

0.15(3.74), 1

0.06(0.38), 4

0.10(0.72), 3

SNARE interactions in vesicular transport

0.23(3.11), 1

0.00(-1.43), 4

0.00(-1.38), 3

0.06(-0.31), 2

Renal cell carcinoma

0.17(3.09), 1

0.09(1.44), 3

0.08(0.93), 4

0.14(1.90), 2

Notch signaling pathway

0.21(3.04), 2

0.27(5.60), 1

0.03(-0.54), 4

0.12(0.89), 3

Acute myeloid leukemia

0.17(2.74), 2

0.17(3.73), 1

0.06(0.15), 4

0.13(1.43), 3

Endometrial cancer

0.17(2.47), 2

0.17(3.42), 1

0.06(0.29), 4

0.10(0.58), 3

Dorso-ventral axis formation

0.22(2.43), 2

0.22(3.11), 1

0.09(0.71), 3

0.09(0.06), 4

Apoptosis

0.13(1.95), 2

0.04(-0.77), 3

0.03(-1.19), 4

0.19(3.63), 1

Fc epsilon RI signaling pathway

0.09(0.57), 4

0.08(0.70), 3

0.17(4.40), 1

0.15(2.23), 2

Small cell lung cancer

0.06(-0.54), 3

0.11(2.27), 2

0.04(-0.70), 4

0.20(4.31), 1

  1. a The rank of the pathway gene set enrichment of the compared methods according to the corresponding Meet/Min values' z-scores. The bold font denotes the enriched pathways (z-score > 3.0).